TY - JOUR AU - Mahran, Mona A. AU - Ismail, Mohamed Teleb AU - Abdelkader, Elwy H. PY - 2019 DA - 2019/12/21 TI - 100 years of sickle cell disease research: etiology, pathophysiology and rational drug design (part 1) JO - Beni-Suef University Journal of Basic and Applied Sciences SP - 22 VL - 8 IS - 1 AB - Sickle cell disease (SCD) is a chronic hemolytic disease caused by an altered hemoglobin molecule (HbS) and was first termed as a molecular disease. Glutamic acid in the normal hemoglobin molecule (HbA), was replaced by valine in HbS at the sixth position of both β-chains. This alteration was proved to be due to a single point mutation GTG instead of GAG in the genetic code. Since the discovery of sickle cell disease in 1910, great efforts have been done to study this disease on a molecular level. These efforts aimed to identify the disease etiology, pathophysiology, and finally to discover efficient treatment. Despite the tremendous work of many research groups all over the world, the only approved drug up to this moment, for the treatment of SCD is the hydroxyurea. SN - 2314-8543 UR - https://doi.org/10.1186/s43088-019-0016-x DO - 10.1186/s43088-019-0016-x ID - Mahran2019 ER -