Thymus vulgaris extract modulates dexamethasone induced liver injury and restores the hepatic antioxidant redox system

Beni-Suef University Journal of Basic and Applied Sciences

Table 2 The defensive role of thyme aqueous extract on liver lipid peroxidation, liver glutathione levels, liver glutathione S-transferase, catalase, glutathione peroxidase, and glutathione reductase activities in normal and dexamethasone (DXM)-treated rats

Treatments
Parameters	Lipid peroxidation (nmol/g) (tissue/hr)	% change	Glutathione reduced (nmol/g tissue)	% change	Glutathione S-transferase IU/gm tissue	% change	Catalase in liver (IU/gm tissue)	% change	Glutathione peroxidase (IU/gm tissue)	% change	Glutathione reductase (IU/gm tissue)	% change
G1 Normal	13.13 ± 1.07	-	33.47 ± 3.65	-	4.12 ± 0.161	-	0.800 ± 0.004	-	171.5 ± 8.43	-	317.2 ± 12.59	-
G2 Dexamethasone	25.72 ± 1.65^***	95.89	18.49 ± 1.44 ^**	− 44.76	2.34 ± 0.166 ^***	− 43.20	0.213 ± 0.056 ^***	− 73.38	81.57 ± 6.07^***	− 52.44	180.1 ± 5.73^***	-43.22
G3 Thyme	22.39 ± 1.56	− 12.95	34.95 ± 0.936 ^***	89.02	3.69 ± 0.252 ^***	57.69	0.303 ± 0.526 ^**	− 42.25	131.5 ± 13.80 ^**	61.21	290.4 ± 16.61 ^***	61.24
F-Probability	P < 0.6424	-	P < 0.0002	-	P < 0.0001	-	P < 0.0001	-	P < 0.2094	-	P < 0.0001	-

Data are expressed as mean ± standard error. Number of animals in each group is ten. Mean, which have the same superscript symbol(s), are not significantly different. Percentage changes (%) were calculated by comparing normal group with DXM-treated group and pre-treated DXM groups with DXM-treated group