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Table 3 Effect of test compounds on carrageenan induced rat paw edema

From: Synthesis, characterization, and investigation of the anti-inflammatory effect of 2,3-disubstituted quinazoline-4(1H)-one

Groups

Paw volume (ml)

0 h

½ h

1 h

2 h

3 h

4 h

5 h

24 h

Control

0.18

0.18

0.18

0.18

0.18

0.18

0.18

0.18

Positive control

0.30 ± 0.017

0.34 ± 0.010

0.41 ± 0.014

0.47 ± 0.016

0.51 ± 0.014

0.52 ± 0.014

0.54 ± 0.010

0.26 ± 0.008

Diclofenac (20 mg/kg)

0.28 ± 0.008

0.28 ± 0.008*

0.24 ± 0.016**

0.21 ± 0.012**

0.25 ± 0.013**

0.31 ± 0.014**

0.34 ± 0.020**

0.23 ± 0.018

Test G1 (5 mg/kg)

0.30 ± 0.008

0.33 ± 0.008

0.37 ± 0.016

0.35 ± 0.012

0.36 ± 0.020

0.42 ± 0.016

0.47 ± 0.017

0.25 ± 0.008

Test G1 (10 mg/kg)

0.30 ± 0.008

0.32 ± 0.008

0.36 ± 0.015

0.33 ± 0.015*

0.34 ± 0.020**

0.38 ± 0.016*

0.44 ± 0.015

0.26 ± 0.008

Test G1 (20 mg/kg)

0.30 ± 0.008

0.30 ± 0.013

0.34 ± 0.023*

0.31 ± 0.014**

0.31 ± 0.016**

0.36 ± 0.017**

0.40 ± 0.016**

0.26 ± 0.012

Test G2 (5 mg/kg)

0.30 ± 0.010

0.33 ± 0.011

0.37 ± 0.007

0.38 ± 0.012

0.36 ± 0.016

0.44 ± 0.036

0.49 ± 0.040

0.28 ± 0.008

Test G2 (10 mg/kg)

0.30 ± 0.010

0.33 ± 0.013

0.36 ± 0.009

0.35 ± 0.012*

0.33 ± 0.016**

0.41 ± 0.036*

0.46 ± 0.020

0.30 ± 0.008

Test G2 (20 mg/kg)

0.31 ± 0.010

0.32 ± 0.011

0.35 ± 0.007*

0.33 ± 0.012*

0.35 ± 0.016**

0.38 ± 0.036**

0.42 ± 0.040*

0.29 ± 0.008

Test G3 (5 mg/kg)

0.29 ± 0.008

0.34 ± 0.013

0.38 ± 0.023

0.36 ± 0.014

0.35 ± 0.016

0.41 ± 0.017

0.46 ± 0.016

0.26 ± 0.012

Test G3 (10 mg/kg)

0.30 ± 0.008

0.33 ± 0.012

0.36 ± 0.024

0.34 ± 0.015*

0.32 ± 0.016**

0.38 ± 0.019**

0.42 ± 0.014*

0.25 ± 0.012

Test G3 (20 mg/kg)

0.32 ± 0.008

0.31 ± 0.013

0.33 ± 0.023*

0.31 ± 0.014**

0.30 ± 0.016**

0.36 ± 0.017**

0.49 ± 0.016**

0.27 ± 0.012

  1. Values are expressed as mean ± SEM (n = 6) and ANOVA followed by Dunnett’s test
  2. *p < 0.05, **p < 0.001 when compared with the control group