Groups | Paw volume (ml) | |||||||
---|---|---|---|---|---|---|---|---|
0 h | ½ h | 1 h | 2 h | 3 h | 4 h | 5 h | 24 h | |
Control | 0.18 | 0.18 | 0.18 | 0.18 | 0.18 | 0.18 | 0.18 | 0.18 |
Positive control | 0.30 ± 0.017 | 0.34 ± 0.010 | 0.41 ± 0.014 | 0.47 ± 0.016 | 0.51 ± 0.014 | 0.52 ± 0.014 | 0.54 ± 0.010 | 0.26 ± 0.008 |
Diclofenac (20 mg/kg) | 0.28 ± 0.008 | 0.28 ± 0.008* | 0.24 ± 0.016** | 0.21 ± 0.012** | 0.25 ± 0.013** | 0.31 ± 0.014** | 0.34 ± 0.020** | 0.23 ± 0.018 |
Test G1 (5 mg/kg) | 0.30 ± 0.008 | 0.33 ± 0.008 | 0.37 ± 0.016 | 0.35 ± 0.012 | 0.36 ± 0.020 | 0.42 ± 0.016 | 0.47 ± 0.017 | 0.25 ± 0.008 |
Test G1 (10 mg/kg) | 0.30 ± 0.008 | 0.32 ± 0.008 | 0.36 ± 0.015 | 0.33 ± 0.015* | 0.34 ± 0.020** | 0.38 ± 0.016* | 0.44 ± 0.015 | 0.26 ± 0.008 |
Test G1 (20 mg/kg) | 0.30 ± 0.008 | 0.30 ± 0.013 | 0.34 ± 0.023* | 0.31 ± 0.014** | 0.31 ± 0.016** | 0.36 ± 0.017** | 0.40 ± 0.016** | 0.26 ± 0.012 |
Test G2 (5 mg/kg) | 0.30 ± 0.010 | 0.33 ± 0.011 | 0.37 ± 0.007 | 0.38 ± 0.012 | 0.36 ± 0.016 | 0.44 ± 0.036 | 0.49 ± 0.040 | 0.28 ± 0.008 |
Test G2 (10 mg/kg) | 0.30 ± 0.010 | 0.33 ± 0.013 | 0.36 ± 0.009 | 0.35 ± 0.012* | 0.33 ± 0.016** | 0.41 ± 0.036* | 0.46 ± 0.020 | 0.30 ± 0.008 |
Test G2 (20 mg/kg) | 0.31 ± 0.010 | 0.32 ± 0.011 | 0.35 ± 0.007* | 0.33 ± 0.012* | 0.35 ± 0.016** | 0.38 ± 0.036** | 0.42 ± 0.040* | 0.29 ± 0.008 |
Test G3 (5 mg/kg) | 0.29 ± 0.008 | 0.34 ± 0.013 | 0.38 ± 0.023 | 0.36 ± 0.014 | 0.35 ± 0.016 | 0.41 ± 0.017 | 0.46 ± 0.016 | 0.26 ± 0.012 |
Test G3 (10 mg/kg) | 0.30 ± 0.008 | 0.33 ± 0.012 | 0.36 ± 0.024 | 0.34 ± 0.015* | 0.32 ± 0.016** | 0.38 ± 0.019** | 0.42 ± 0.014* | 0.25 ± 0.012 |
Test G3 (20 mg/kg) | 0.32 ± 0.008 | 0.31 ± 0.013 | 0.33 ± 0.023* | 0.31 ± 0.014** | 0.30 ± 0.016** | 0.36 ± 0.017** | 0.49 ± 0.016** | 0.27 ± 0.012 |