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Table 7 analgesic activity of various Rauvolfia species by formalin test

From: Identification of suitable substitute for Sarpagandha (Rauvolfia serpentina (L.) Benth. ex Kurz) by phytochemical and pharmacological evaluation

  Before treatment After treatment
10 min 20 min 30 min 40 min 50 min 60 min 10 min 20 min 30 min 40 min 50 min 60 min
GP I (control) 15.0 ± 1.4 12.1 ± 1.7 5.8 ± 1.1 14.1 ± 1.7 12.0 ± 1.7 19.3 ± 2.5# 10.3 ± 2.7 3.1 ± 1.9 5.5 ± 1.8 2.5 ± 1.6 5.6 ± 1.7 10.6 ± 3.7
GP II (Standard) 1.5 ± 0.5 2.5 ± 1.5 2.6 ± 1.5 2.3 ± 0.8 2.0 ± 1.2 3.1 ± 1.7 1.3 ± 1.2 3.3 ± 1.2 3.0 ± 1.4 2.1 ± 1.1* 2.6 ± 1.7* 2.1 ± 1.4*
GP III (RHR) 10.6 ± 1.7 15.6 ± 3.0 13.1 ± 3.1 15.1 ± 3.4 10.6 ± 1.7 11.0 ± 2.3 14.0 ± 2.2 5.3 ± 2.1 4.8 ± 2.0 16.3 ± 3.6 12.0 ± 2.6 3.1 ± 1.1*
GP IV (RTR) 12.6 ± 1.7 16.6 ± 4.0 11.3 ± 2.0 10.6 ± 2.1 11.5 ± 1.2 18.6 ± 1.8 12.3 ± 1.7 1.8 ± 1.1* 8.1 ± 2.7 10.5 ± 2.8 8.8 ± 2.4 3.5 ± 1.0*
GP V (RSR) 14.5 ± 3.0 14.8 ± 1.9 9.6 ± 1.6 10.8 ± 1.6 16.1 ± 4.0 10.0 ± 2.2 8.0 ± 2.0 6.0 ± 1.2 8.1 ± 1.1 6.1 ± 2.4* 12.0 ± 1.7 8.8 ± 1.8
GP VI (RMR) 12.5 ± 1.8 13.3 ± 2.4 7.6 ± 1.6 7.6 ± 2.2 7.8 ± 0.7 7.5 ± 1.8 8.3 ± 1.2 5.8 ± 2.1 3.0 ± 1.7* 1.6 ± 1.0* 1.8 ± 1.1* 1.8 ± 0.7*
GPVII (RVR) 7.5 ± 1.5 7.1 ± 1.4 8.1 ± 2.4 6.5 ± 1.5 7.5 ± 1.0 5.3 ± 1.5 2.5 ± 1.8 2.8 ± 0.7* 2.1 ± 0.7* 2.1 ± 1.7* 1.3 ± 0.8* 1.1 ± 1.1*
  1. Values are mean ± SD, n = 6
  2. #p < 0.05 when compared to GPI normal
  3. *p < 0.05 when compared to GP-II control by ANOVA followed by Dunnett’s post-test