Fig. 3
Role of resistin, TLR4, and NF-κB signalings in the development of inflammation. 
: Stimulation/release 
: Restore/repair; 
: Stimulation; 
: Inhibition. FGF21 fibroblast growth factor 21, FGFR fibroblast growth factor receptor gene, Akt protein kinase B, ERK extracellular signal-regulated kinases, MD2 myeloid differentiation factor 2, TLR4 Toll-like receptor 4, TRIRAP Toll/interleukin-1 receptor domain-containing adapter protein, NF-kB nuclear factor kappa-light-chain-enhancer of activated B cells, Ik-B IκB kinase, mTORC1 Mammalian target of rapamycin complex 1, AMPK AMP-activated protein kinase, PI3K phosphatidylinositol-3-kinase, JAK c-Jun N-terminal kinases, MyD88 myeloid differentiation primary response 88, DR diabetic retinopathy, APPl1 adaptor protein, phosphotyrosine interacting, IR insulin resistance, α-MSH & CART α-melanocyte-stimulating hormone & cocaine and amphetamine-regulated transcript, AgRP& NPY Agouti-related protein & neuropeptide Y, GHSR growth hormone secretagogue receptor, POMC proopiomelanocortin, FA-O in SK.M skeletal muscle lipid oxidation, SoCS3 suppressor of cytokine signaling 3, PTP1B protein tyrosine phosphatase 1B, ER endoplasmic reticulum