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Table 1 Pharmacological activities of C.gigantea

From: Calotropis gigantea assisted green synthesis of nanomaterials and their applications: a review

Part of plantPharmacological ActivityPharmacological model usedReference
FlowersAnalgesicAcetic acid induced writhing[15]
FlowersAnti-tumoricEhrlich’s ascites carcinoma in mice[16]
LatexAntibacterialAgar well diffusion method using cariogenic bacteria[17]
LeavesAntibacterialAgar well diffusion method using Klebsiella spp[18]
FlowersAnti-fungalDisc diffusion assay method using Aspergillus flavus and Aspergillus fumigatus[10]
FlowersCytotoxicityBrine shrimp lethality bioassay
Aerial partsAntipyreticTAB (typhoid) vaccine-induced pyrexia in rabbits and Brewer’s yeast-induced pyrexia in rats[19]
Root barkAntitumourEhrlich’s ascites carcinoma in mice[20]
Peeled rootsAnticonvulsant and skeletal muscle relaxant activityPentobarbitone-induced sleeping time model and rotating rod model[21]
LeavesAnticonvulsant and skeletal muscle relaxant activityMaximal electroshock seizure (MES) and Strychnine-induced convulsions models and rotating rod model[22]
LeavesCytostatic and cytotoxic activitySRB assay using tumour cell lines: MDA-MB-231 (human breast cancer), PC-3 (human prostate cancer), MCF7 (human breast cancer), HT-29 (human colon cancer), 4 T1 (mouse mammary cancer), and RAW-267 (mouse leukemic monocyte macrophage)[23]
LeavesAntiplasmodialLactate dehydrogenase assay using human blood[24]
Latex and fruitsHIF-1 inhibitory activitiesT47D cell-based dual-luciferase reporter assay[25]
Root barkWound healingExcision, incision and dead space wound models[26]
RootsPregnancy interceptionPostcoital contraceptive efficacy evaluation[27]
LatexProcoagulant activityRe-calcification time and fibrinogenolytic activity[28]