Table 1 Grouping and treatment schedule

I. Normal control

Rats were maintained on a standard diet without any treatment

II. Diabetic control

Uninephrectomised rats were administered with STZ (55mg/kg, single dose)+insulin (2–4 U/day) for 24 weeks

III. Oleamide per se

Normal rats administered with oleamide (5mg/kg, i.p) for 24 weeks

IV. AM6545 per se

Normal rats were administered AM-6545 (16 mg/kg, i.p.) for 24 weeks

V. Oleamide 1mg/kg

The uninephrectomised diabetic rats treated with oleamide (1mg/kg, i.p.,) for 24weeks

VI. Oleamide 2.5 mg/kg

The uninephrectomised diabetic rats treated with oleamide (2.5mg/kg, i.p., ) for 24weeks

VII. Oleamide 5 mg/kg

The uninephrectomised diabetic rats treated with oleamide (5mg/kg, i.p.,) for 24weeks

VIII. AM-6545, 4mg/kg

The uninephrectomised diabetic rats treated with AM-6545 (4mg/kg, i.p.,) for 24 weeks

IX. AM-6545, 8mg/kg

The uninephrectomised diabetic rats treated with AM-6545 (8mg/kg, i.p.,) for 24weeks

X. AM-6545, 16mg/kg

The uninephrectomised diabetic rats treated with AM-6545 (16mg/kg, i.p.,) for 24weeks

XI. (Oleamide+AM-4565)

The uninephrectomised diabetic rats treated with a combination of oleamide (5mg/kg, i.p) and AM-6545 (16mg/kg) for 24weeks