Table 1 Diazepam withdrawal scoring
Activity | Score |
|---|---|
Vocalization | |
 No abnormality | 0 |
 Mild | 1 |
 Intermediate | 2 |
 Severe | 3 |
Agitation | |
 No agitation | 0 |
 Rats showing irritable agitation | 1 |
 Handling vocalization/very aggressive | 2 |
 Spontaneous vocalization and very aggressive | 3 |
Ear-twitching (shaking or trembling of ear) | |
 Absence | 0 |
 Mild | 1 |
 Intermediate | 2 |
 Severe | 3 |
Fascicular twitch (shaking or trembling of nape) | |
 Absence | 0 |
 Mild | 1 |
 Intermediate | 2 |
 Severe | 3 |
Tremors | |
 No tremor | 0 |
 Normal body vibrations | 1 |
 Tremor and rigidity | 2 |
 Severe shivering or shaking | 3 |
Handling-induced clonic convulsion | |
 Absence | 0 |
 Rats showing only wild running | 1 |
 Rats showing tonic-clonic seizure | 2 |
 Rats showing severe tonic-clonic seizure \90 S | 3 |
Spontaneous clonic convulsion | |
 Absence | 0 |
 Rats showing only wild running | 1 |
 Rats showing tonic-clonic seizure | 2 |
 Rats showing severe tonic-clonic seizure \90 S | 3 |
Abnormal posture | |
 Normal posture | 0 |
 Mild head-down, back-hunched | 1 |
 Moderate head-down, back-hunched | 2 |
 Prominent head-down, back-hunched | 3 |