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Table 2 Effects of agmatine administration on brain GABA and glutamate concentration in diazepam withdrawal rats

From: Inhibition of NMDA receptors by agmatine is followed by GABA/glutamate balance in benzodiazepine withdrawal syndrome

 

Water

Diazepam

Water

Agmatine

Water

Agmatine

GABA

18.3 ± 2.7

23.7 ± 4.7

5.6 ± 1.1b

21.6 ± 4.7a

Glutamate

35.14 ± 3.14

43.04 ± 1.42

77.37 ± 4.29b

53.94 ± 3.92a,b

  1. Values are expressed as means ± SD (n = 12). Significant differences by Tukey’s test: ap < 0.01, from water controls to agmatine-treated animals; bp < 0.01, from water-pretreated controls to diazepam withdrawal animals following one-way ANOVA