Fig. 2

Drug–gene interaction network visualized using Cytoscape. The nodes represent drugs and target genes and the edges represent drug–gene association. To differentiate between the two kinds of nodes, the drug nodes are shaped like an ellipse and the target gene nodes are shaped in a round rectangular fashion. The darker nodes are hub nodes that play an essential role in connecting node clusters in the network. Memantine (node degree = 29, betweenness centrality = 0.54) and quetiapine (node degree = 26, betweenness centrality = 0.39) form important hub nodes as they target GABAergic and acetylcholine receptors with donepezil as the bridge drug for the two clusters