Investigating drug–target interactions in frontotemporal dementia using a network pharmacology approach

Balasubramanian, Archana; Sudarshan, Raksha; Chatterjee, Jhinuk

doi:10.1186/s43088-021-00145-4

Beni-Suef University Journal of Basic and Applied Sciences

Table 1 Summary of frontotemporal dementia drugs, FDA status and number of targets based on DrugBank annotation

From: Investigating drug–target interactions in frontotemporal dementia using a network pharmacology approach

Sl. No	DrugBank ID	Generic name	FDA status	# Targets
1	DB00556	Perflutren	Approved	-
2	DB12401	Bromperidol	Approved, investigational	No annotation
3	DB01043	Memantine	Approved, investigational	7
4	DB00372	Thiethylperazine	Approved, withdrawn	1
5	DB00699	Nicergoline	Approved, investigational	1
6	DB01381	Ginkgo biloba	Approved, investigational, nutraceutical	6
7	DB01068	Clonazepam	Approved, illicit	3
8	DB00777	Propiomazine	Approved	6
9	DB00656	Trazodone	Approved, investigational	8
10	DB00620	Triamcinolone	Approved, vet approved	1
11	DB08842	Acetylcarnitine	Approved, investigational	-
12	DB00674	Galantamine	Approved	4
13	DB00382	Tacrine	Approved, investigational, withdrawn	3
14	DB06016	Cariprazine	Approved, investigational	6
15	DB12710	Perazine	Approved, investigational	No annotation
16	DB12867	Benperidol	Approved, investigational	No annotation
17	DB01121	Phenacemide	Approved	1
18	DB00377	Palonosetron	Approved, investigational	1
19	DB00122	Choline	Approved, nutracitical	8
20	DB00889	Granisetron	Approved, investigational	1
21	DB08870	Brentuximab vedotin	Approved, investigational	1
22	DB00904	Ondansetron	Approved	5
23	DB00433	Prochlorperazine	Approved, vet approved	4
24	DB00843	Donepezil	Approved	8
25	DB00989	Rivastigmine	Approved, investigational	2
26	DB01209	Dezocine	Approved, investigational	2
27	DB11584	Pipradrol	Approved	1
28	DB01224	Quetiapine	Approved	24
29	DB00734	Risperidone	Approved, investigational	13
30	DB09210	Piracetam	Approved, investigational	-
31	DB11239	Aluminium sulphate	Approved	-
32	DB13668	Ipidacrine	Experimental	No annotation
33	DB12969	Methylinositol	Investigational	No annotation
34	DB11756	Solanezumab	Investigational	No annotation
35	DB12034	Gantenerumab	Investigational	No annotation
36	DB04859	Zanapezil	Investigational	1
37	DB13084	Pyritinol	Investigational	No annotation
38	DB12958	Prothipendyl	Investigational	No annotation
39	DB06106	AIT-034	Investigational	No annotation
40	DB12311	CP1-1189	Investigational	No annotation
41	DB05432	DAS-431 IV	Investigational	1
42	DB12930	Opipramol	Investigational	No annotation
43	DB12555	Nelotanserin	Investigational	1
44	DB16214	Landipirdine	Investigational	No annotation
45	DB06504	S-8510	Investigational	No annotation
46	DB11758	Cenicriviroc	Investigational	No annotation
47	DB05180	LX6171	Investigational	-
48	DB06465	FK-960	Investigational	No annotation
49	DB08831	2-deoxyglucose	Experimental, investigational	-
50	DB06247	CX516	Investigational	1
51	DB05814	GPI-1485	Investigational	1
52	DB05450	Smilagenin	Investigational	No annotation
53	DB12613	Davunetide	Investigational	No annotation
54	DB04892	Phenserine	Investigational	3
55	DB12129	Tideglusib	Investigational, withdrawn	1

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