Table 3 Enriched KEGG pathways in target genes of FTD drugs as identified by WebGestalt
Gene Set | Description | Size | Expect | Ratio | p value | FDR |
|---|---|---|---|---|---|---|
hsa04080 | Neuroactive ligand–receptor interaction | 277 | 2.9 | 19.9 | 0 | 0 |
hsa04024 | cAMP signalling pathway | 199 | 2.1 | 10.3 | 0 | 0 |
hsa04020 | Calcium signalling pathway | 183 | 1.9 | 11.2 | 0 | 0 |
hsa05032 | Morphine addiction | 91 | 0.9 | 18.4 | 0 | 0 |
hsa05033 | Nicotine addiction | 40 | 0.4 | 58.3 | 0 | 0 |
hsa04727 | GABAergic synapse | 88 | 0.9 | 16.9 | 4.4E−16 | 2.4E−14 |
hsa04726 | Serotonergic synapse | 115 | 1.2 | 12.9 | 4.0E−14 | 1.9E−12 |
hsa04723 | Retrograde endocannabinoid signalling | 148 | 1.6 | 10.7 | 1.5E−13 | 6.2E−12 |
hsa04742 | Taste transduction | 83 | 0.9 | 13.5 | 5.1E−11 | 1.8E−09 |
hsa05030 | Cocaine addiction | 49 | 0.5 | 19.0 | 6.5E−11 | 2.1E−09 |