Table 4 Historeceptomics analysis displaying target regions of the top 5 drugs in the drug–gene network

Memantine

Adrenal cortex, appendix, cardiac myocytes,cd33 myeloid, heart, liver, occipital lobe, pituitary, prefrontal cortex, skeletal muscle, skin, thyroid, whole brain

CDKL3, DRD2,GABRA1, GABRA2,GABRA3, GABRA4,GABRA5,GABRA6,GABRB1,GABRB2,GABRB3,GABRD,GABRE,GABRG1,GABRG2,GABRG3,GABRP,GABRQ,GLRA1,GLRA2,GLRA3,GLRB,HTR3A

Quetiapine

Adipocyte, cardiac myocytes,cd33 myeloid, foetal brain, foetal liver, heart, liver, lymph node, pineal, prefrontal cortex, skeletal muscle, superior cervical ganglion, uterus, whole brain

ADRA1D,ADRA2A,CHRM2,CHRM3,CHRM5,DRD5,HTR1B,HTR1D,HTR1E,HTR3A

Donepezil

Amygdala, bdca4, dendritic cells, cd33 myeloid,cd4t cells, cingulate cortex, foetal brain, heart, liver, occipital lobe, skeletal muscle, smooth muscle, superior cervical ganglion, thyroid, uterus, whole blood

GRIN1,GRIN2A,GRIN2B,GRIN2C,GRIN2D,GRIN3A,HTR2A,IL1B,NFKB1,NFKB2,NOS1,TNFAIP6

Risperidone

Adrenal cortex, bronchial epithelial cells, cd14 monocytes, cd33 myeloid, cd34, cd56 NK cells, cerebellum, cerebellum peduncles, foetal brain, heart, kidney, liver, lung, pancreas, pineal, pituitary, placenta, prostate, retina, thyroid, whole blood, whole brain

ADRB2,APOD,BCL6,BRD3,BRD4,CDC42,CDKL2,CETP,DCK,ERBB2,FKBP4,GLTP,GRM1,GSTA1,GSTP1,MET,MIF,NQO2,OGG1,PARP1,SRC,SRK10TNKS2,VDR,ZAP70

Clonazepam

Amygdala, appendix, cardiac myocytes, cerebellum, cerebellum peduncles, heart, liver, medulla oblongata, occipital lobe, pancreas, pituitary, placenta, prefrontal cortex, skeletal muscle, skin, superior cervical ganglion, trachea, whole brain

GABRA1,GABRA2,GABRA3,GABRA4,GABRA5,GABRA6,GABRB1,GABRB2,GABRB3,GABRD,GABRE,GABRG1,GABRG2,GABRG3,GABRP,GABRQ