Skip to main content
Beni-Suef University Journal of Basic and Applied Sciences
Fig. 1 | Beni-Suef University Journal of Basic and Applied Sciences

Fig. 1

From: In silico screening and molecular docking study of compounds from Pedalium murex L. with Vasopressin2 receptor target for Autosomal Dominant Polycystic Kidney Disease

Fig. 1

Vasopressin2 receptor signalling in autosomal dominant polycystic kidney disease. Dissociation of polycystin complex (PC1 and PC2) and binding of Gα subunit of GPCR with PC1 subsequently leads to the aberrant increase in the level of cAMP. The pathogenic activation of the Vasopressin2 receptor causes an abnormal increase in vasopressin levels, as well as an increase in cAMP levels. Cyclic AMP (cAMP)-driven mechanisms are central to the pathogenesis of ADPKD. It affects the functionality of SLC12A1 renal transporter, i.e. a regulator of Na:K:Cl co-transporter

Back to article page