Fig. 4

A–D Photomicrographs of a liver sections of G4 (X 400, H&E). A focuses on the eroded CV which is accompanied with heavy accumulation of mononucleated cells. Generally, the hepatocytes’ nuclei in such necrotic area exhibit abnormal chromatin distribution. B shows a CV that displays eroded endothelium lining (white arrows). The mononuclear cells invade the eroded area around the central vein. Generally, most of the hepatocytes are shrunken, degenerated and darkly stained; this is accompanied with widening of the BS. Notice that the hepatocytes’ nuclei are pleomorphic. C shows a dilated CV that displays a marked thickening of its endothelial lining cells (arrows). The central vein’s lumen is largely occluded with a mass of blood clot which, apart from a few remains of red blood cells, is homogeneous, hyaline and acidophilic. D shows a necrotic area of hepatocytes (arrows). Most of the hepatocytes are highly evacuated (vanished cytoplasm)