Fig. 5

A–G Photomicrographs of T. S. of kidneys of rats of G1 showing part of the cortices (C, H&E). A The cortex is characterized by the presence of numerous glomeruli (G). (X 100, H&E). B A magnified part of the cortex of A exhibit normal typical structure of G, proximal convoluted tubules (P) and distal convoluted tubules (D). (X 400, H&E). C A photomicrograph of T. S. of kidney of G2 showing proximal (P) & distal (D) tubular necrosis with variable degrees of stainability. The necrotic cells fell into the tubules’ lumen and obliterated them (*). Notice the vacuolar changes (arrows), the G degeneration and capsular thickening. (X 100, G2, H&E). D A photomicrograph of T. S. of kidney of G3 showing moderate alterations restricted to few spots per each examined section, and hypercellularity (*). The glomerular alterations include clefted and shrunken glomeruli (G and arrow, respectively). (X 100, G3, H&E). E A photomicrographs of T. S. of kidneys of G4 showing sever degradation of the kidney tubules (white-arrows). In most cases, the tubules show obliterated lumina (black asterisk), and hypercellularity in between. The interstitial areas among the renal tubules together with the lumina of the renal tubules were congested with blood cells (white asterisk). Notice the cellular infiltration (thin black arrow). (X 100, G4). F & G showing degenerated, widened, and thickened BVs, plus severe vacuolar degeneration. Notice variable degrees of necrotic changes in both sections. The interstitial areas among the renal tubules together with the lumina of the renal tubules were congested with blood cells. (X 400 and 100; respectively, G4)