Skip to main content

Table 1 Binding affinity of Cajanus cajan derived compounds to HDAC1, HDAC3, HDAC8 and HDAC7

From: In silico profiling of histone deacetylase inhibitory activity of compounds isolated from Cajanus cajan

  

Binding affinity (Kcal/mol)

S/N

Compounds

HDAC1

HDAC3

HDAC8

HDAC7

S

Givinostat (inhibitor)

 − 11.9

 − 13.3

 − 13.4

 − 14.0

S

Trichostatin A (inhibitor)

 − 10.9

 − 12.8

 − 10.1

 − 11.8

1

2-hydroxygenistein

 − 10.5

 − 10.8

 − 10.0

 − 10.8

2

Betulinic acid

 − 15.4

 − 14.8

 − 15.9

 − 15.8

3

Biochanin A

 − 10.6

 − 10.2

 − 10.1

 − 11.2

4

Cajaninstilbene acid

 − 10.2

 − 11.1

 − 9.7

 − 10.0

5

Cajanol

 − 10.9

 − 10.9

 − 10.3

 − 11.1

6

Cajanuslactone

 − 11.2

 − 11.0

 − 11.8

 − 10.9

7

Genistein

 − 10.3

 − 10.2

 − 10.1

 − 10.4

8

Genistin

 − 13.4

 − 13.4

 − 12.7

 − 14.0

9

Longistylin A

 − 11.2

 − 11.0

 − 11.9

 − 10.9

10

Longistylin C

 − 10.9

 − 11.1

 − 10.8

 − 10.3

11

Orientin

 − 12.6

 − 13.4

 − 13.6

 − 13.4

12

Pinostrobin

 − 10.5

 − 10.5

 − 10.2

 − 11.0

13

Vitexin

 − 12.3

 − 13.6

 − 13.0

 − 13.2

  1. Bold indicates phytocompounds from C. cajan with binding scores greater HDAC known inhibitor (Givinostat)