Skip to main content

Table 5 Pharmacokinetics effect of piperine on different drugs

From: Molecular and pharmacological aspects of piperine as a potential molecule for disease prevention and management: evidence from clinical trials

Drug

Dose (Piperine + Drug, duration)

ROA

Methods of detection

Plasma level

References

Propranolol

20 mg + 40 mg, 7 days

oral

Spectrofluorimetric method

1000–1200 ng mL−1 h

Bano et al. [184]

Theophylline

20 mg + 150 mg, 7 days

Oral

EMIT

*80–90 μg mL−1 h

Bano et al. [184]

Diclofenac

20 mg + 100 mg, 10 days

Oral

NCAM, Phoenix WinNonlin 6.2 software

7.09–11.81 μg mL−1 h

Satish Kumar Bedada et al. [155, 156]

CBZ

20 mg + 200 mg, 10 days

Oral

NCAM, Phoenix®, WinNonlin 6.4® software

40–70 μg mL−1 h

Bedada et al. [155, 156]

Emodin

20 mg/kg + 20 mg/kg, 1 day

Oral

LC–MS/MS

1913–2555 ng mL−1 h

Di et al. [185]

Linarin

20 mg/kg + 50 mg/kg, 1 day

Oral

NCAM, DAS 2.1.1

Software, ANOVA

240–934 ng mL−1 h

Feng et al. [186]

Curcumin

In rats-20 mg/kg + 2 g/kg, 1 day

In humans- 5 mg + 500 mg, 1 day

Oral

MIM, PHARMKIT computer programme with SIMPLEX algorithm

3.33–3.95 μg mL−1 h

0.07–0.09 μg mL−1 h

Shoba et al. [187]

Cannabidiol

10 mg/kg + 15 mg/kg, 10 days

Oral

NCAM, WinNonlin® (version 5.2,

Pharsight, Mountain View, CA)

Acute- 576–610

Ng mL−1 h

Chronic- 722–896

ng mL−1 h

Izgelov et al. [36]

Fexofenadin

10 mg/kg + 10 mg/kg

10 mg/kg + 5 mg/kg, 1 day

Oral

oral + IV

NCAM, WinNonlin® (version 5.2, Pharsight, Mountain View, CA)

687–1353 ng mL−1 h

5670–9830 ng mL−1 h

Jin and Han [188]

Sodium valproate

5 mg/kg + 150 mg/kg, 1 day

Oral

NCAM, trapezoidal method

1024 μg mL−1.h

Parveen et al. [37]

OXR

10 mg/kg + 100 mg/kg

1 mg/kg + 10 mg/kg, 1 day

Oral

IV

NCAM, PK Solution 2.0 software (Summit Research Service)

9375.27 ± 1974.32 μg h/L

1471.00 ± 1945.62 μg h/L

Junsaeng et al. [38]

  1. *Serum concentration