Drug | Dose (Piperine + Drug, duration) | ROA | Methods of detection | Plasma level | References |
---|---|---|---|---|---|
Propranolol | 20 mg + 40 mg, 7 days | oral | Spectrofluorimetric method | 1000–1200 ng mL−1 h | Bano et al. [184] |
Theophylline | 20 mg + 150 mg, 7 days | Oral | EMIT | *80–90 μg mL−1 h | Bano et al. [184] |
Diclofenac | 20 mg + 100 mg, 10 days | Oral | NCAM, Phoenix WinNonlin 6.2 software | 7.09–11.81 μg mL−1 h | |
CBZ | 20 mg + 200 mg, 10 days | Oral | NCAM, Phoenix®, WinNonlin 6.4® software | 40–70 μg mL−1 h | |
Emodin | 20 mg/kg + 20 mg/kg, 1 day | Oral | LC–MS/MS | 1913–2555 ng mL−1 h | Di et al. [185] |
Linarin | 20 mg/kg + 50 mg/kg, 1 day | Oral | NCAM, DAS 2.1.1 Software, ANOVA | 240–934 ng mL−1 h | Feng et al. [186] |
Curcumin | In rats-20 mg/kg + 2 g/kg, 1 day In humans- 5 mg + 500 mg, 1 day | Oral | MIM, PHARMKIT computer programme with SIMPLEX algorithm | 3.33–3.95 μg mL−1 h 0.07–0.09 μg mL−1 h | Shoba et al. [187] |
Cannabidiol | 10 mg/kg + 15 mg/kg, 10 days | Oral | NCAM, WinNonlin® (version 5.2, Pharsight, Mountain View, CA) | Acute- 576–610 Ng mL−1 h Chronic- 722–896 ng mL−1 h | Izgelov et al. [36] |
Fexofenadin | 10 mg/kg + 10 mg/kg 10 mg/kg + 5 mg/kg, 1 day | Oral oral + IV | NCAM, WinNonlin® (version 5.2, Pharsight, Mountain View, CA) | 687–1353 ng mL−1 h 5670–9830 ng mL−1 h | Jin and Han [188] |
Sodium valproate | 5 mg/kg + 150 mg/kg, 1 day | Oral | NCAM, trapezoidal method | 1024 μg mL−1.h | Parveen et al. [37] |
OXR | 10 mg/kg + 100 mg/kg 1 mg/kg + 10 mg/kg, 1 day | Oral IV | NCAM, PK Solution 2.0 software (Summit Research Service) | 9375.27 ± 1974.32 μg h/L 1471.00 ± 1945.62 μg h/L | Junsaeng et al. [38] |