Table 7 Pharmacokinetic parameters of piperine in rodents
Route of administration | Dose (mg/kg) | Cmax (μg/mL) | Tmax (h) | t1/2 (h) | AUC0-∞ (μg h/mL) | References |
|---|---|---|---|---|---|---|
Oral | 20 | 1.10 | 2.00 | 1.27 | 7.20 | Ren and Zuo [191] |
Oral | 54.4 | 4.29 ± 0.97 | 2.45 ± 2.12 | 4.10 ± 0.94 | 23.1 ± 0.1 |  |
Intravenous | 10 | 2.90 | – | 8 | 15.6 |  |
Intravenous | 3.5 | 5.90 ± 1.76 | – | 1.68 ± 0.40 | 3.80 ± 0.84 |  |
Intra-peritoneal | 20 | 0.051 ± 0.009 | 3.00 ± 0.17 | - | 1.22 |  |