Fig. 1
From: The role of protein phosphatase 2A tau axis in traumatic brain injury therapy
Mechanism of PP2A tau modulation in TBI. Interaction of PP2A subunits with a variety of cellular proteins, and binding of specific PP2A inhibitors and modulatory proteins to the catalytic subunit, all combine to modulate PP2A catalytic activity and ensure PP2A isoform-specific targeting and substrate specificity. Specific modulatory proteins also critically regulate PP2A biogenesis, and many compounds, like sodium selenite, ferulic acid, are known to enhance PP2A catalytic activity