Costus root extract improves testicular toxicity of Bisphenol A in adult male albino rats: histopathological, ultrastructural and biochemical studies

Beni-Suef University Journal of Basic and Applied Sciences

Table 3 Effect of the treatment with Bisphenol A alone or together with costus root extract on levels of testosterone, FSH, PRL, and LH

	First (control) group	Second group costus root extract	Third group Bisphenol A	Fourth group Bisphenol A with costus root extract
Testosterone	4.01 ± 0.3 (nmoI/L)	4.13 ± 0.03 (nmoI/L)	2.2 ± 0.02* (nmoI/L)	3.9 ± 0.01** (nmoI/L)
FSH	018.03 ± 0.21 (IU/L)	018.9 ± 0.11 (IU/L)	017.1 ± 0.01 (IU/L)	16.11 ± 0.01** (IU/L)
PRL	16.18 ± 0.48 (mIU/L)	16.08 ± 0.03 (mIU/L)	15.91 ± 0.2 (mIU/L)	14.91 ± 0.4** (mIU/L)
LH	21.9 ± 0.14 (IU/L)	22.01 ± 0.01 (IU/L)	20.19 ± 0. 2 (IU/L)	019.9 ± 0.1** (IU/L)

The first group received distilled water daily for eight weeks
The second group was treated with Costus root extract at a dose (0.4 mg/kg) daily
The third group was treated with 10 mg/kg of Bisphenol A (BPA) (body weight /day) dissolved in 5 ml/kilogram of oil of olive
The fourth group received 10 mg/kg of Bisphenol A (bwt/day) Costus root extract at a dose (0.4 mg/kg) daily for eight weeks was given by gastric gavage daily
^*p < 0.05 (significant difference in comparison with control group and second groups)
^**p < 0.05 (significant difference in comparison with third group)