Table 3 Preferred codons for each amino acid in the ORF4 of HEV-hosts

Phe

UUU(F)

0

3.9

5.2

UUC(F)

3

5.7

4.4

Leu

UUA(L)

3

3.3

1

UUG(L)

8

7.4

8.5

CUU(L)

1

2.9

1.8

CUC(L)

1

5.6

2.2

CUA(L)

3

7

5.3

CUG(L)

4

7.6

5

Iso

AUU(I)

3

4.3

4.8

AUC(I)

3

3.7

4.8

AUA(I)

0

3.6

4.8

Val

GUU(V)

0

2.6

2

GUC(V)

1

0.3

3.4

GUA(V)

1

2.3

1

GUG(V)

3

4.1

2.2

Ser

UCU(S)

0

2.4

5.7

UCC(S)

4.4

3.7

1.5

UCA(S)

5

1.3

4

UCG(S)

5.6

3.7

1.7

AGU(S)

4

0

0

AGC(S)

3

6.1

4.6

Pro

CCU(P)

4

4.4

4.6

CCC(P)

11

3.1

5

CCA(P)

5

3.1

2.2

CCG(P)

10

3.7

2

Thr

ACU(T)

1

1

1

ACC(T)

3.2

1.7

2.4

ACA(T)

2

3.4

1.2

ACG(T)

4

3.6

1.8

Ala

GCU(A)

4

2

1.8

GCC(A)

5

6.7

5.8

GCA(A)

1

3.6

3

GCG(A)

3

1.6

1.8

Tyr

UAU(Y)

1

1

1

UAC(Y)

0

3

4

His

CAU(H)

0

0.1

0.2

CAC(H)

0

0.6

3.3

Gln

CAA(Q)

1

0.7

1.7

CAG(Q)

5

1.9

8.3

Asn

AAU(N)

0

0

0

AAC(N)

1

0.9

0.4

Lys

AAA(K)

0

0

0

AAG(K)

1

2

0.2

Asp

GAU(D)

1

2.3

3

GAC(D)

0

0.1

0

Glu

GAA(E)

0

0.1

1

GAG(E)

2

2.6

3.5

Cys

UGU(C)

0

1.7

3

UGC(C)

7

5

3

Arg

CGU(R)

1

1

2

CGC(R)

2

7.1

8.5

CGA(R)

2

0.7

0.2

CGG(R)

2

5.4

4.7

AGA(R)

1

0.1

1

AGG(R)

2

6.6

6.8

Gly

GGU(G)

1

1.7

2

GGC(G)

5

5

3

GGA(G)

1

0

2

GGG(G)

4

2.7

2.5