Synthesis, characterization and antibiotic evaluation of some novel (E)-3-(4-diphenylamino)phenyl)-1-(4′-fluorophenyl)prop-2-en-1-one chalcones and their analogues

Beni-Suef University Journal of Basic and Applied Sciences

Table 1 Physical data of the synthesized triphenylamine chalcones

Sample	B-ring	M.F	M.W (g)	Color	R_f	M.P range	Yield (%)
1a	4-Bromoacetophenone	C₂₇H₂₀BrNO	454	Deep yellow	0.67	145–147	70
1b	3-Nitroacetophenone	C₂₇H₂₀N₂O₃	420	Golden yellow	0.76	143–145	92
1c	4-Chloroacetophenone	C₂₇H₂₀ClNO	409	Yellow	0.69	137–139	57
1d	4-Fluoroacetophenone	C₂₇H₂₀FNO	393	Lemon green	0.83	136–138	60
2a	4-Hydroxypropiophenone	C₂₉H₂₅NO₂	419	Pale yellow	0.72	146–148	55
2b	2-Bromopropiophenone	C₂₉H₂₄BrNO	482	Brownish yellow	0.45	147–148	30
2c	4-methoxypropiophenone	C₃₁H₂₇NO₂	433	Orange yellow	0.75	142–144	52
2d	4-Flouropropiophenone	C₂₉H₂₄FNO	421	Cotton brown	0.64	146–148	54

M.F: molecular formula, M.W: molecular weight, M.P: melting point, R_f: retention factor