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Table 6 Comparison of the proposed methods to other reported methods for TIG determination in intravenous infusion solution

From: In situ green analytical methods for the rapid and sensitive determination of a newly launched orphan anticancer drug; Tigecycline in infusion bags: comparative study

Parameters

Proposed methods

Reported methods

Analytical reagent

CE method: –––

RP-HPLC [7]: 1-Hexane sulfonic acid sodium monohydrate salt

Stability-Indicating RP-LC [8]:–––

UPLC-PDA [9]: –––

AUC Spectrophotometric method [10]: –––

Thermal analysis Spectrophotometric method [11]: Copper acetate reagent for visible method

Fluorimetric method [12]: –––

Spectrophotometric method

Method I: –––

Method II: –––

Method III: MBTH (chromogenic reagent)

λmax

CE method: 245 nm

RP-HPLC [7]: 247 nm

Stability-Indicating RP-LC(8): 280 nm

UPLC-PDA [9]: 350 nm

AUC Spectrophotometric method [10]:between 240 to 256 nm

Thermal analysis Spectrophotometric method [11]: 245 nm for UV method and 378 nm for visible method

Fluorimetric method [12]: λex = 333 nm and λem = 453 nm

Spectrophotometric methods

Method I: from peak to peak at 334–372 nm

Method II ∆A: from peak to peak at 342–401 nm

Method II D1: from peak to peak at 279–311 nm

Method III: 409 nm

Linearity range

CE method: 5–300 µg/mL

RP-HPLC [7]:40–60 µg/mL

Stability-Indicating RP-LC [8]: 40–100 µg/mL

UPLC-PDA [9]: 0.024 to 6 µg/mL

AUC Spectrophotometric method [10]: 4–20 µg/mL

Thermal analysis Spectrophotometric method [11]: 10–22 µg/mL for UV method and 10–34 µg/mL for visible method

Fluorimetric method [12]: 0.1–2.0 µg/mL

Spectrophotometric methods

Method I: 20–200 µg/mL

Method II ∆A and D1: 40–140 µg/mL

Method III: 20–140 µg/mL

LOQ

CE method: 3.25 µg/mL

RP-HPLC [7]: 5.42 µg/mL

Stability-Indicating RP-LC [8]: 5.05 µg/mL

UPLC-PDA [9]: 0.024 µg/mL

AUC Spectrophotometric method [10]: 0.08 µg/mL

Thermal analysis Spectrophotometric method [11]:1.00 µg/mL for UV method and 0.89 µg/mL for visible method

Fluorimetric method [12]: 0.1 µg/mL

Spectrophotometric methods

Method I: 11.46 µg/mL

Method II ∆A: 17.02 µg/mL

Method II D1: 15.58 µg/mL

Method III: 20.00 µg/mL

LOD

CE method: 0.98 µg/mL

RP-HPLC [7]: 1.8 µg/mL

Stability-Indicating RP-LC [8]: 1.67 µg/mL

UPLC-PDA [9]: 0.006 µg/mL

AUC Spectrophotometric method [10]: 0.02 µg/mL

Thermal analysis Spectrophotometric method [11]:0.33 µg/mL for UV method and 0.29 µg/mL for visible method

Fluorimetric method [12]: 0.033 µg/mL

Spectrophotometric methods

Method I: 3.78 µg/mL

Method II ∆A: 5.62 µg/mL

Method II D1: 5.14 µg/mL

Method III: 8.06 µg/mL

Correlation coefficient

CE method: 0.9999

RP-HPLC [7]: 0.9999

Stability-Indicating RP-LC [8]: 0.9997

UPLC-PDA [9]: > 0.995

AUC Spectrophotometric method [10]: 0.9991

Thermal analysis Spectrophotometric method [11]: 0.9998 for UV method and 0.9997 for visible method

Fluorimetric method [12]: 0.9997

Spectrophotometric methods

Method I: 0.9997

Method II ∆A: 0.9995

Method II D1: 0.9994

Method III: 0.9990