Table 2 List of top 10 genes with a greater number of functional interactors in the gene interaction network of DEGs in T2DM-TB

ITGAM

Integrin alpha M

73

GPR97, CYBB, MMP9, ATP8B4, CERCAMB, SLC2A3, CD68, CLAME, CLEC5A, CLEA12A, BST1, MRO, ARG1, MCEMF1, SELP, RAP1B, CLEC4D, OLR1, ATP6AP2, RAP20, MGAM, CD69, CR1, GPR84, TOM1, P2RX1, SLC11A1, DEGS1, LILRB2, CEACAM1, JAM13, TLR4, CCR1, CD36, LAMTOP3, CEACAM13, ITGB5, NBEA1, PLAUR, CTLA4, IL-7R, CCR7, C3AR1, CCR2, ITHAX, ITGB3, IL-1β, TLR8, CPN, FPR2, CD5, CD19, ITGB7, IL-15, TLR7, TLR1, CD14, FGER1G, CXCL-10, IL-10, CD28, CD2, CD3E, STAT1, FCGR1A, ANPEP, CD48, HMGB1, CD40LG, CD44, IRF8, SLAMF1

FPR2

N-formyl peptide receptor 2

68

CXCL10, CCR7, C3AR1, CCR2, ITGAX, FCER1G, TLR8, ITGAM, PLAUR, NBEAL2, CEACAM3, LAMTOR3, CD36, CCR1, GPR84, TOM1, P2RX, SLC11A1, DEGS1, LILRB2, CEACAM1, MCEMP1, MGAM, RAP20, ATP6AP2, OLR1, CLEC4D, CLEC5A, CLEC12, BST1, MCEMP1, SLC2A3, CEACAM8, ATP8B4, CYBB, GPR97, GNB4, GPR18, P2RY14, CAMP, ADCY3, HEBP1, PPBP, S1PR1, CCL4L1, P2RY13, LPAR5, S1PR5, HCAR3, FPR1, GPR65, GNG7, F2ML, CCR3, HCAR2, GNAI3, CXCR1, CXCL16, PTGDR2, CXCR6, GNG11, GPR68, P2RY10, FFAR2, PNOC, GPR183, CXCR5

STAT1

Signal transducer and activator of transcription 1-alpha/beta

64

CXCR3, PTGS2, IL-1β, ITGAM, ISG15, FGFR10P2, IL-10, LAP3, EGF, IRF8, PLCG1, TLR8, EIF2AK2, IFI44L, SOCS3, CXCL10, OASL, IRF7, JAK2, SOCS1, LCK, BCL8, MAPK14, CUX1, RUNX2, STAT4, IL-2Rβ, UBE2E1, TRIM25, UBE2L6, IFI35, HERC5, OSM, OAM, OAS3, MX1, GBP2, XAF1, IFIH1, GBP5, OAS1, IFI6, IFGAX, STAT2, GBP1, IL-10Rβ, IFNAR1, IL-23A, LMC4, IFNLR1, CISH, TRIM22, RSAD2, IL-23A, LMC4, IFNLR1, CISH, TRIM22, RSAD2, IGIT3, IGIT1, PSMB9, SP110, IFIT2, IFIT2, IFI44, SAMD9L, PARP9, PARP14

C3AR1

C3a anaphylatoxin chemotactic receptor

62

TLR4, CD86, ITGAM, CXCL10, CXCR3, RAR1B, CD68, CYBB, CEACAMB, CCR3, PTGDR2, CXCR5, CCR1, CCR7, C3AR1, CLEC5A, CLEC4D, GPR84, CD36, OLR1, CEACAM1, GNB4, ADCY3, GNA13, GPR183, TOM1, CCR2, LAMTOR3, P2RX1, CEACAN3, DEGS1, PLAUR, CCLAL1, PPBP, P2RY14, HEBP1, FPR1, HCAR3, HCAR2, GNG11, P2RY13, FCER1G, GNG7, GPR18, CXCR6, S1PR1, PNOC, LPAR5, S1PR5, CXB1

PPBP

Platelet basic protein

59

CAMP, MMP9, SELP, CXCL10, CXCR3, FPR2, CCR3, PTGDR2, CXCR5, CXCL16, SERP1NG1, OLFM4, MMRN1, GAS6, VEGFB, FAM49B, PROSI, FTH1, OSCAR, HP, GNB4, CCR1, CCR7, C3AR1, CDA, LRG1, FOLR3, QPCT, CTSD, METL7A, TCN1, PGLYRF1, ADCY3, GNAI3, GPR183, CCR2, TNFAIF6, VWF, CYFIP1, F13A, F5, ORM1, CCL41, P2RY14, HEBP1, FPR1, HCAR3, HCAR2, GNG11, P2RY13, EGF, GNG7, GPR18, CXCR6, S1PR1, PNOC, LPAR5, S1PR5, CXCR1

HERC5

E3 ISG15–protein ligase HERC5

59

KCTD6, CUL5, WWP1, PLCG1, STAT1, ANAPC1, EIF2AK2, IFI44L, FDXO7, FBXL5, SOCS1, ISG14, IRF7, OAS1, RNF138, SOCS3, TRIP12, U8E2E1, TRIM25, UBE2L6, IFI35, IFIT1, OAS3, MX1, PJA1, UBE2G2, FBXL3, TRIM21, RSAD2, IFIT3, EF4G2, IFI6, OAS1, RBCK1, IFCH1, XAF1, FBXO9, UBA6, CBLB, UBE2Q2, UBE2K, UBE20, FBXO31, EF4E3, IFI44, SAMD9L, CDC26, ASB8, KLHL2, FLNB, IFIT2, KBTBD9L, UBE4A, RNF213, MEX3C, PJA2, ANAPC1B, KLHL5

SOCS3

Suppressor of cytokine signalling 3

56

TRIP12, RNF13B, SOCS1, FBXL5, FBXO6, KCTD6, CUL5, WWP1, STAT1, ANAPC1, FBXO7, UBE2E, UBE2L6, HERC5, PJA1, UBE2G2, FBXL3, TRIM21, RBCK1, FBXO9, UBA6, CBLB, UBE2Q2, UBE2K, UBE20, FBXO31, CDC26, ASBB, KLHL3, ANAPC1, PJA2, MEX3C, RNF213, UBE4A, KBTBD7, KLHL2, IL-10, PTGS3, IL-1β, IRF1, JAK2, OSM, STAT2, LCK, IL2RB, LMO4, IL-23A, IFNAR1, CISH

IL-10

Interleukin-10

55

MAPK14, CCR7, CTLA4, PTGS2, IL-1β, STAT1, SOCS3, IL-2Rβ, IFNAR1, ARG1, STAT2, CXCL10, CXCR3, MMP9, CCR2, MPO, IL-1RN, CCR1, CD69, ITGAX, IL-23A, CD19, TLR8, ITGAM, HSPA4, DJSP1, FCGR1A, HLA-G, STAT4, IL-7R, FCFR2, IL-10RB, CCLAL1, EGF, IFNLR1, TLR5, CASP, FPR1, CD86, CD44, TLR1, TLR7, CD28, IL-15, TLR4, CD40LG, NFL3, PROM1, LILRB2, PRF1, CD27, CD83, CD68, TNFSF13B, NOD2

TRIM21

E3 ubiquitin-protein ligase TRIM21

55

HLA-G, KCTD6, CUL5, WWP1, FCGR1A, ANAPC1, CD44, FBXO7, TRAR1, SOCS3, IRF1, FBXO6, FBXL5, SOCS1, HLA-C, HLA-F, GBP4, RNF138, MT2A, TRIP12, IFI30, FCGR1B, UBE2E1, UBE2L6, IEF7, HERC5, OASL, OAS3, OAS1, PJA1, UBE2G2, GBP5, FBXL3, IFI35, GBP1, IRF8, RBCK1, GBP2, FBXO9, UBA6, CBLB, UBE2Q2, UBE2K, UBE20, FBXO31, CDC26, ASB8, KLML2, KBTBD7, UBE4A, RNF213, MEX3C, PJA2, ANAPC1, KLHL3

CXCL-10

C-X-C motif chemokine 10

54

CXCR3, MMP9, CCR2, CCR1, TLR4, TLR8, IL-15, IL-1β, IL-10, CD86, FPR1, IFI44L, GBP5, CCR7, STAT1, FBR2, CCR3, PTGDR2, CXCR5, CXCL16, OASL, IRF7, ISG15, RSAD2, CXCR5, CXCL16, OASL, IRF7, ISG15, RSAD2, IFIT3, IFIT1, MX1, CCL4L1, ADCY3, GNAI3, GPR183, OAS1, GBR1, C3AR1, IRF1, IFIT2, IFIH1, ITGAM, PPBP, P2RY14, HEBP1, HCAR3, HCAR2, GNG11, P2RY13, GNG7, GPP18, CXCR6, S1PR1, PNOC, LPAR5, S1PR5, CXCR1