Beni-Suef University Journal of Basic and Applied Sciences

Table 2 Effect of different treatments on the levels of brains TOS, TAC, serotonin, dopamine and norepinephrine in the different experimental groups

From: Alpha-lipoic acid-role in improving both reserpine toxicity and paroxetine treatment in the cerebral cortex of albino rats; histological, ultrastructural, immunohistohemical and biochemical studies

Groups	Parameters
Groups	TOS μmol/g tissue	TAC μmol/g tissue	Serotonin μg/g	Dopamine μg/g	Norepinephrine μg/g
Control	5.51 ± 0.68	64.83 ± 10.06	94.17 ± 12.31	210.50 ± 33.17	287.00 ± 25.06
ALA	5.31 ± 1.03	65.33 ± 11.20	93.33 ± 12.94	207.33 ± 27.63	298.00 ± 22.38
Reserpine	27.68 ± 4.20**	34.17 ± 5.49**^b	45.17 ± 9.17**	108.17 ± 15.58**	110.00 ± 16.21**
Reserpine + Paroxetine	21.83 ± 4.62**^a	33.50 ± 5.28**^b	84.67 ± 13.50**a	156.67 ± 39.02** ^a	232.17 ± 43.37*^a
Reserpine + Paroxetine + ALA	6.25 ± 0.59^a	54.67 ± 5.08*^a	104.17 ± 27.65**^a	195.50 ± 23.88^a	258.83 ± 47.91**^a

n = 8 animals for each group
(*) P < 0.01 and (**) P < 0.0001 significant comparing with control group
^a P < 0.0001 and ^b P < 0.001 significant comparing with reserpine group

Back to article page