Antihyperglycemic activity of verbenone and L-arginine in nicotinamide-streptozotocin-induced diabetic mice: in vitro and in vivo studies

Beni-Suef University Journal of Basic and Applied Sciences

Table 1 Effects of verbenone, L-arginine and ratios of verbenone + L-arginine (1:1 v/m) on blood glucose levels (mg/dL) of NAD-STZ-induced diabetic mice

	Day 0	Day 1			Day 7	Day 13	Day 15
		1 h	2 h	24 h
Control	127 ± 08	120 ± 05^a	130 ± 06^a	124 ± 05^a	130 ± 05^a	138 ± 06^a	120 ± 06^a
Diabetic untreated	315 ± 06	300 ± 09^b	308 ± 09^b	427 ± 10^b	502 ± 16^b	572 ± 16^b	533 ± 11^b
Glibenclamide 5 mg/kg bwt	291 ± 06	195 ± 04^c	233 ± 06^c	289 ± 16^c	239 ± 10^c	203 ± 11^c	158 ± 23^a
Verbenone 100 mg/kg bwt	395 ± 07	346 ± 09^d	377 ± 11^d	95 ± 05^d	57 ± 07^d	282 ± 16^d	244 ± 11^c
L-arginine 100 mg/kg bwt	356 ± 03	456 ± 10^e	562 ± 16^e	521 ± 12^e	442 ± 12^e	388 ± 10^e	521 ± 25^b
L-arginine 200 mg/kg bwt	346 ± 04	190 ± 06^c	322 ± 12^f	426 ± 07^b	305 ± 11^f	536 ± 19^b	424 ± 10^d
Ratio (1:1 v/m) 100 mg/kg bwt	413 ± 05	343 ± 13^d	386 ± 13^g	540 ± 12^e	391 ± 10^g	583 ± 22^b	511 ± 11^b
Ratio (1:1 v/m) 200 mg/kg bwt	367 ± 04	233 ± 09^f	192 ± 06^h	479 ± 10^f	183 ± 08^h	183 ± 06^f	226 ± 05^c

Values are mean ± SEM, n = 5; Ratio (1:1 v/m) = verbenone + L-arginine (1:1 v/m)
Values with different superscript down the column are significantly different at p > 0.05