From: Cardioprotective effects of Ferulic acid against various drugs and toxic agents
S.No | Author | Year | Model used | Cardiotoxic agent | Dose of Ferulic acid used | Major Mechanism/Effect | Reference |
---|---|---|---|---|---|---|---|
1 | Yogeeta et al | 2006 | Wistar albino rats | Isoproterenol | 20Â mg/kg body weight | Reducing oxidative stress and improving cellular antioxidants | [37] |
2 | Yogeeta et al | 2006 | Wistar albino rats | Isoproterenol | 20Â mg/kg body weight | Reducing lipid peroxidation and modifying lipid and lipoprotein metabolism | [38] |
3 | Yogeeta et al | 2006 | Wistar albino rats | Isoproterenol | 20Â mg/kg body weight | Improving mitochondrial stability by decreasing oxidative stress and increasing mitochondrial antioxidants | [39] |
4 | Yogeeta et al | 2006 | Wistar albino rats | Isoproterenol | 20Â mg/kg body weight | Cytoprotective effect by modulating membrane bound phosphatases and lysosomal hydrolases | [40] |
5 | Jain et al | 2018 | Sprague Dawley rats | Isoproterenol | 10, 20 and 40Â mg/kg body weight | Reducing oxidative stress and inflammation | [41] |
6 | Zhang et al | 2021 | Sprague Dawley rats | Isoproterenol | 5, 25 and 50Â mg/kg body weight | Reducing oxidative stress, regulating apoptosis and activating Nrf2 signaling pathway | [42] |
7 | Aswar et al | 2019 | Wistar albino rats | Doxorubicin | 20, 40Â mg/kg body weight | Modulation of oxidative stress, inflammation, ER stress and calcium homeostasis | [45] |
8 | Song et al | 2016 | ICR mice | Cyclophosphamide | 50 and 100Â mg/kg body weight | Suppressing IKk/IkB/NF-kB pathway and reducing inflammation | [49] |
9 | Pannerselvam et al | 2020 | Wistar albino rats | Arsenic | 10, 20 and 40Â mg/kg body weight | Restoring cellular antioxidants, ATP levels and modulation of AMPK signaling pathway | 51 |
10 | Perumal et al | 2021 | Zebrafish | Arsenic | 30 μM | Modulating oxidative stress and regulating cardio genesis | 52 |
11 | Chowdhury et al | 2016 | Wistar albino rats | Streptozotocin | 50Â mg/kg body weight | Modifying oxidative stress, hyperlipidemia and regulating PI3K/Akt dependent signaling cascade | 54 |
12 | Alam et al | 2013 | Wistar albino rats | N(ÏŽ)-nitrol-L-arginine methyl ester hydrochloride | 0.8Â g/kg of food | Decreasing oxidative stress, preventing inflammation and increasing antioxidant s | 57 |
13 | Li et al | 2020 | H9c2 cells/ C57BL/6 mice | TNF-alpha/Cycloheximide | 50 μM | Reducing oxidative stress and stimulating autophagy by regulating Akt/mTOR signaling pathway | 61 |
14 | Sun et al | 2021 | H9c2 cells/ C5/BL/6 J mice | Hydrogen peroxide/Isoprenaline | 50 μM/30 mg/kg body | By modulating miR-499-5p/p21 signaling pathway | 62 |