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Table 1 Summary of the cardioprotective effects of Ferulic acid against various drugs and chemicals

From: Cardioprotective effects of Ferulic acid against various drugs and toxic agents

S.No

Author

Year

Model used

Cardiotoxic agent

Dose of Ferulic acid used

Major Mechanism/Effect

Reference

1

Yogeeta et al

2006

Wistar albino rats

Isoproterenol

20 mg/kg body weight

Reducing oxidative stress and improving cellular antioxidants

[37]

2

Yogeeta et al

2006

Wistar albino rats

Isoproterenol

20 mg/kg body weight

Reducing lipid peroxidation and modifying lipid and lipoprotein metabolism

[38]

3

Yogeeta et al

2006

Wistar albino rats

Isoproterenol

20 mg/kg body weight

Improving mitochondrial stability by decreasing oxidative stress and increasing mitochondrial antioxidants

[39]

4

Yogeeta et al

2006

Wistar albino rats

Isoproterenol

20 mg/kg body weight

Cytoprotective effect by modulating membrane bound phosphatases and lysosomal hydrolases

[40]

5

Jain et al

2018

Sprague Dawley rats

Isoproterenol

10, 20 and 40 mg/kg body weight

Reducing oxidative stress and inflammation

[41]

6

Zhang et al

2021

Sprague Dawley rats

Isoproterenol

5, 25 and 50 mg/kg body weight

Reducing oxidative stress, regulating apoptosis and activating Nrf2 signaling pathway

[42]

7

Aswar et al

2019

Wistar albino rats

Doxorubicin

20, 40 mg/kg body weight

Modulation of oxidative stress, inflammation, ER stress and calcium homeostasis

[45]

8

Song et al

2016

ICR mice

Cyclophosphamide

50 and 100 mg/kg body weight

Suppressing IKk/IkB/NF-kB pathway and reducing inflammation

[49]

9

Pannerselvam et al

2020

Wistar albino rats

Arsenic

10, 20 and 40 mg/kg body weight

Restoring cellular antioxidants, ATP levels and modulation of AMPK signaling pathway

51

10

Perumal et al

2021

Zebrafish

Arsenic

30 μM

Modulating oxidative stress and regulating cardio genesis

52

11

Chowdhury et al

2016

Wistar albino rats

Streptozotocin

50 mg/kg body weight

Modifying oxidative stress, hyperlipidemia and regulating PI3K/Akt dependent signaling cascade

54

12

Alam et al

2013

Wistar albino rats

N(ÏŽ)-nitrol-L-arginine methyl ester hydrochloride

0.8 g/kg of food

Decreasing oxidative stress, preventing inflammation and increasing antioxidant s

57

13

Li et al

2020

H9c2 cells/ C57BL/6 mice

TNF-alpha/Cycloheximide

50 μM

Reducing oxidative stress and stimulating autophagy by regulating Akt/mTOR signaling pathway

61

14

Sun et al

2021

H9c2 cells/ C5/BL/6 J mice

Hydrogen peroxide/Isoprenaline

50 μM/30 mg/kg body

By modulating miR-499-5p/p21 signaling pathway

62