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Table 1 Solubility of vorinostat in oils, surfactants, and co-surfactants

From: Improved oral bioavailability of poorly water-soluble vorinostat by self-microemulsifying drug delivery system

Vehicle Function in SMEDDS Avg. solubility (mg/mL)*
Oleic acid Oil 1.268 ± 0.142
Castor oil Oil 0.448 ± 0.002
Capryol 90 Oil 1.666 ± 0.058
Tween 20 Surfactant 1.337 ± 0.014
Span 20 Surfactant 1.734 ± 0.145
Labrasol Surfactant 1.612 ± 0.128
1,2 Propylene glycol Co-surfactant 1.865 ± 0.012
Polyethylene glycol 200 Co-surfactant 1.840 ± 0.026
Polyethylene glycol 400 Co-surfactant 2.169 ± 0.138
  1. *Each value represents the mean ± SD (n = 3)