Skip to main content
Beni-Suef University Journal of Basic and Applied Sciences

Table 1 Solubility of vorinostat in oils, surfactants, and co-surfactants

From: Improved oral bioavailability of poorly water-soluble vorinostat by self-microemulsifying drug delivery system

Vehicle

Function in SMEDDS

Avg. solubility (mg/mL)*

Oleic acid

Oil

1.268 ± 0.142

Castor oil

Oil

0.448 ± 0.002

Capryol 90

Oil

1.666 ± 0.058

Tween 20

Surfactant

1.337 ± 0.014

Span 20

Surfactant

1.734 ± 0.145

Labrasol

Surfactant

1.612 ± 0.128

1,2 Propylene glycol

Co-surfactant

1.865 ± 0.012

Polyethylene glycol 200

Co-surfactant

1.840 ± 0.026

Polyethylene glycol 400

Co-surfactant

2.169 ± 0.138

  1. *Each value represents the mean ± SD (n = 3)
Back to article page