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Table 2 Self-emulsification time, appearance, and phase separation of vorinostat-loaded SMEDDS

From: Improved oral bioavailability of poorly water-soluble vorinostat by self-microemulsifying drug delivery system

Formulation code Self-emulsification time (min)* Appearance Phase separation for 24 h#
F1 1.95 ± 0.26 Bluish white NPS
F2 1.38 ± 0.12 Bluish white NPS
F3 2.58 ± 0.51 Bluish white NPS
F4 2.27 ± 0.02 Bluish white NPS
F5 Large oil droplets NPS
F6 1.08 ± 0.01 Bluish white NPS
F7 1.47 ± 0.05 Clear and transparent NPS
F8 1.18 ± 0.01 Clear and transparent NPS
F9 Large oil droplets NPS
F10 Large oil droplets NPS
F11 1.30 ± 0.05 Clear and transparent NPS
F12 0.88 ± 0.06 (53 ± 4 s) Clear and transparent NPS
  1. Each value represents the mean ± SD (n = 3)
  2. *Self-emulsification time (s)
  3. #NPS no phase separation