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Beni-Suef University Journal of Basic and Applied Sciences

Table 3 The pH of vorinostat-loaded SMEDDS in different media

From: Improved oral bioavailability of poorly water-soluble vorinostat by self-microemulsifying drug delivery system

Media

pH

SMEDDS in media (1:1000)

F7

F8

F11

F12

UPW

7.7

5.37 ± 0.050

5.21 ± 0.049

5.40 ± 0.034

5.35 ± 0.035

0.1 M HCl

1.15

1.20 ± 0.105

1.22 ± 0.030

1.21 ± 0.030

1.21 ± 0.061

PB

6.8

6.70 ± 0.120

6.85 ± 0.122

6.78 ± 0.085

6.80 ± 0.121

  1. Each value represents the mean ± SD (n = 3)
  2. UPW ultra-pure water, PB phosphate buffer, HCl hydrochloric acid
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