Ameliorative effects of Artemisia and Echinacea extracts against hepato and cardiotoxicity induced by DMBA on albino rats: experimental and molecular docking analyses

Beni-Suef University Journal of Basic and Applied Sciences

Table 5 ADMET properties of all studied compounds

	Caco2 permeability	Intestinal absorption	Skin Permeability	P-glycoprotein substrate	P-glycoprotein substrate	P-glycoprotein I inhibitor	VDss (human)	Fraction unbound (human)
Artelinic acid	1.024	89.132	− 2.758	Yes	No	No	1.41	0.385
Artemiside	1.19	88.84	− 3.17	Yes	No	No	1.11	0.331
Artemisone	1.27	98.08	− 2.60	No	No	No	1.17	0.17
Artemotil	1.38	89.79	− 3.11	No	Yes	No	1.11	0.23
Artenimol	1.28	98.69	− 2.36	No	Yes	Yes	0.61	0.05
Caffeic acid	0.88	88.46	− 2.73	Yes	Yes	Yes	− 0.76	0.33
Caftaric acid	0.99	90.86	− 2.73	Yes	Yes	Yes	− 0.52	0.35
Chicoric acid	1.33	99.28	− 2.56	Yes	No	Yes	0.11	0.22
Chlorogenic acid	1.26	90.92	− 2.98	Yes	Yes	No	1.32	0.32
Echinacoside	1.26	100.00	− 2.73	No	No	Yes	0.76	0.34