Skip to main content

Table 6 ADMET properties of all studied compounds

From: Ameliorative effects of Artemisia and Echinacea extracts against hepato and cardiotoxicity induced by DMBA on albino rats: experimental and molecular docking analyses

Compounds

BBB

CYP2D6 substrate

CYP3A4 substrate

CYP1A2 inhibitor

AMES toxicity

Oral Toxicity (LD50)

Hepatotoxicity

Skin Sensitization

Artelinic acid

 − 0.70

No

No

Yes

No

2.44

No

No

Artemiside

0.07

No

Yes

Yes

No

2.55

Yes

No

Artemisone

0.30

No

Yes

No

No

2.89

Yes

No

Artemotil

1.38

No

Yes

No

No

3.19

Yes

No

Artenimol

0.26

No

Yes

No

Yes

2.52

No

No

Caffeic acid

0.88

No

Yes

Yes

No

2.51

No

No

Caftaric acid

0.89

no

No

yes

no

2.46

No

No

Chicoric acid

0.54

No

Yes

Yes

No

2.10

No

No

Chlorogenic acid

0.97

No

No

Yes

No

2.44

No

No

Echinacoside

0.71

No

Yes

Yes

No

2.55

Yes

No