Table 1 Search strategy for each database

PubMed

#1 "chronic hepatitis B"[MeSH Terms] OR "entecavir"[All Fields] OR "hepatocellular carcinoma"[All Fields] OR " serological conversion "[All Fields]

#2 "tenofovir disoproxil fumarate"[MeSH Terms] OR "chronic hepatitis B"[All Fields] OR "biochemical response"[All Fields] OR "virological response"[All Fields]

#3 #1 AND #2

Embase

'chronic hepatitis B'/exp OR 'entecavir'/exp OR 'hepatocellular carcinoma'/exp OR 'serological conversion'

#2 'tenofovir disoproxil fumarate'/exp OR 'biochemical response'/exp OR 'virological response'

#3 #1 AND #2

Cochrane library

(chronic hepatitis B):ti,ab,kw (entecavir):ti,ab,kw OR (hepatocellular carcinoma):ti,ab,kw (Word variations have been searched)

#2 (serological conversion):ti,ab,kw OR (tenofovir disoproxil fumarate):ti,ab,kw OR (biochemical response):ti,ab,kw OR (virological response):ti,ab,kw (Word variations have been searched)

#3 #1 AND #2