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Table 3 5-LOX inhibition of the tested compounds

From: Flavonoids as dual inhibitors of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX): molecular docking and in vitro studies

Compounds

% Inhibition of 5-LOX (100 µM)

Compounds

% Inhibition of 5-LOX (100 µM)

Celecoxib

NA

NF7

11.77 ± 2.64

Indomethacin

NA

NPC3

1.11 ± 0.22

Zileuton

98.51 ± 0.14

NPC5

16.41 ± 1.02

NC1

NI

NPC7

16.10 ± 1.73

NC6

NI

NPC6

20.25 ± 7.49

NC7

NI

NPC4

5.07 ± 0.46

NC5

NI

NPC8

26.21 ± 0.27

NC2

5.05 ± 2.59

NP4

35.89 ± 5.65

NC8

4.70 ± 7.72

NP5

3.93 ± 0.71

NF2

2.21 ± 3.71

NP6

20.18 ± 3.88

NF4

NI

NP9

29.52 ± 7.26

NF5

NI

NP7

39.11 ± 3.05

  1. NA Not applicable; NI No inhibitory activity