Table 2 Design matrix of cefuroxime axetil mucoadhesive minitablets by employing Box–Behnken design
Experimental runs | Factor 1 | Factor 2 | Factor 3 | Response 1 | Response 2 | Response 3 |
|---|---|---|---|---|---|---|
A: Conc. of chitosan (mg) | B: conc. of HPMC K 100 M (mg) | C: conc. of sodium CMC (mg) | Friability (%) | Drug content (%) | Mucoadhesive strength (%) | |
1 | 1 | 0 | − 1 | 0.22 | 98.9 | 6.697 |
2 | 1 | − 1 | 0 | 0.22 | 95.3 | 7.256 |
3 | 1 | 1 | 0 | 0.22 | 97.1 | 7.256 |
4 | 0 | 1 | − 1 | 0.19 | 97.1 | 6.697 |
5 | 0 | 0 | 0 | 0.19 | 98.9 | 7.256 |
6 | 0 | − 1 | − 1 | 0.19 | 95.3 | 6.697 |
7 | − 1 | 0 | − 1 | 0.16 | 98.9 | 6.184 |
8 | 0 | − 1 | 1 | 0.19 | 95.3 | 8.674 |
9 | 0 | 1 | 1 | 0.19 | 97.1 | 8.674 |
10 | 1 | 0 | 1 | 0.22 | 98.9 | 8.674 |
11 | 0 | 0 | 0 | 0.18 | 98.9 | 7.256 |
12 | 0 | 0 | 0 | 0.19 | 98.9 | 7.858 |
13 | − 1 | − 1 | 0 | 0.16 | 95.3 | 8.674 |
14 | − 1 | 1 | 0 | 0.18 | 99.4 | 7.256 |
15 | − 1 | 0 | 1 | 0.18 | 98.9 | 8.674 |