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Table 4 Quality control test results of the prepared mucoadhesive minitablets

From: Formulation development, optimization and characterization of mucoadhesive minitablets of cefuroxime axetil: in vitro, ex vivo and in vivo pharmacokinetic evaluation

Formulation code

Hardness (Kg/cm2)*

Friability (%)**

Weight variation***

Drug content (%)****

F1

4.8 ± 0.02

0.16 ± 0.001

21 ± 1.25

96.5 ± 4.29

F2

5.1 ± 0.021

0.21 ± 0.001

21 ± 0.85

97.2 ± 2.96

F3

4.7 ± 0.031

0.19 ± 0.003

21 ± 1.14

98.7 ± 3.82

F4

5.1 ± 0.025

0.3 ± 0.011

21 ± 0.25

98.9 ± 3.81

F5

5.0 ± 0.022

0.22 ± 0.002

21 ± 1.15

99.4 ± 1.95

F6

5.2 ± 0.021

0.18 ± 0.003

21 ± 1.32

95.3 ± 3.89

F7

5.1 ± 0.026

0.22 ± 0.001

21 ± 1.24

97.7 ± 2.31

F8

4.9 ± 0.033

0.21 ± 0.002

21 ± 0.89

98.9 ± 1.95

F9

5.0 ± 0.023

0.32 ± 0.007

21 ± 0.98

99.8 ± 2.56

F10

4.8 ± 0.029

0.26 ± 0.005

21 ± 0.85

97.1 ± 2.93

F11

5.2 ± 0.08

0.19 ± 0.006

21 ± 1.21

97.8 ± 2.97

F12

5.1 ± 0.023

0.27 ± 0.005

21 ± 1.36

96.5 ± 3.72

F13

4.9 ± 0.027

0.18 ± 0.009

21 ± 1.45

95.9 ± 3.29

F14

5.0 ± 0.031

0.34 ± 0.004

21 ± 0.95

98.2 ± 2.31

F15

5.3 ± 0.029

0.29 ± 0.002

21 ± 0.58

99.3 ± 4.51

  1. *Mean ± SD, n = 6, ** Mean ± SD, n = 10, ***Mean ± SD, n = 20, ****Mean ± SD, n = 10