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Table 5 Mucoadhesive strength results of the prepared mucoadhesive minitablets

From: Formulation development, optimization and characterization of mucoadhesive minitablets of cefuroxime axetil: in vitro, ex vivo and in vivo pharmacokinetic evaluation

Formulation code

Mucoadhesive strength (g)*

Force of adhesion (N)*

Bond strength (N/m2)*

F1

6.697 ± 0.24

0.0951 ± 0.0019

3366.15 ± 91

F2

10.168 ± 0.15

0.0997 ± 0.0013

3529.65 ± 84

F3

12.368 ± 0.29

0.2413 ± 0.0018

4293.35 ± 17

F4

18.564 ± 0.18

0.3432 ± 0.0027

5361.38 ± 75

F5

19.741 ± 0.21

0.3449 ± 0.0031

5422.83 ± 63

F6

4.265 ± 0.54

0.0418 ± 0.0067

1480.52 ± 85

F7

5.321 ± 0.86

0.0521 ± 0.0011

1847.09 ± 65

F8

6.124 ± 0.93

0.0599 ± 0.0018

2241.68 ± 91

F9

6.879 ± 0.17

0.0674 ± 0.0033

2387.93 ± 18

F10

7.261 ± 0.29

0.0724 ± 0.0065

2520.53 ± 56

F11

6.184 ± 0.43

0.0606 ± 0.0065

2146.67 ± 74

F12

6.557 ± 0.92

0.0643 ± 0.0014

2276.15 ± 82

F13

7.256 ± 0.17

0.0711 ± 0.0023

2518.82 ± 97

F14

7.858 ± 0.45

0.0770 ± 0.0073

2727.77 ± 18

F15

8.674 ± 0.47

0.0850 ± 0.0081

3011.03 ± 34

  1. *Mean ± SD, n = 6