Table 4 Interleukin IL-10 mean plasma concentrations in controls and OC patients according to gene polymorphism (1082 G/A and 819 C/T)
From: Gene polymorphisms of interleukin 10 (− 819 C/T and − 1082 G/A) in women with ovarian cancer
Genotype | Control | Ovarian cancer | P value |
|---|---|---|---|
(N = 48) | (N = 48) | ||
(Mean ± SE) | (Mean ± SE) | ||
IL-10 (− 819 C/T) (pg/ml) (N) | |||
C/C (20, 3) | 33.07 ± 2.60 | 38.40 ± 3.98 | NS |
C/T (24, 34) | 35.22 ± 1.95 | 51.98 ± 3.32 | P < 0.001 |
T/T (4, 11) | 34.15 ± 5.02 | 43.41 ± 4.00 | NS |
C (44,37) | 34.24 ± 1.58 | 50.88 ± 3.12 | P < 0.001 |
T(28,45) | 35.06 ± 1.78 | 49.88 ± 2.73 | P < 0.001 |
IL-10 (− 1082 G/A) (pg/ml) (N) | |||
G/G (8, 16) | 38.02 ± 2.26 | 45.42 ± 3.12 | NS |
G/A (27, 28) | 33.48 ± 2.24 | 50.27 ± 3.95 | P < 0.001 |
A/A (13, 4) | 32.78 ± 2.50 | 56.40 ± 7.21 | P < 0.05 |
G (35,44) | 34.52 ± 1.82 | 48.51 ± 2.75 | P < 0.001 |
A (40,32) | 33.25 ± 1.70 | 51.04 ± 3.55 | P < 0.001 |
Haplotype | |||
GC (34,14) | 39.16 ± 3.07 | 50.40 ± 5.56 | NS |
AC (36,25) | 33.15 ± 1.82 | 53.58 ± 4.22 | P < 0.001 |
AT (27,30) | 34.67 ± 1.80 | 52.11 ± 3.71 | P < 0.001 |
GT (18,41) | 36.40 ± 2.22 | 49.25 ± 2.91 | P < 0.01 |