Cytotoxic effects of Trachyspermum ammi and Ferula assafoetida on MCF-7 and MDA-MB-468 breast cancer cell lines

Beni-Suef University Journal of Basic and Applied Sciences

Table 4 Cytotoxic effects of Trachyspermum ammi essential oil (TAEO) and Ferula assafoetida essential oil (FAEO) on MCF-7 and MDA-MB-468 breast cancer cell lines

Cell line	Time	CONC (ppm)	TAEO			FAEO			P-value
			Viability %		IC₅₀	Viability %		IC₅₀
			Mean	SD	IC₅₀	Mean	SD	IC₅₀
MCF-7	24 h	Control	100.1	0.89	228.6 ± 21.53	100.96	5.46	> 400	0.72
		100	85	7.58		81.20	2.52		0.44
		200	61.33	6.50		71.89	4.58		0.08
		400	7.19	0.52		71.31	5.56		< 0.0001
	48 h	Control	99.6	0.89	209.8 ± 20	100.01	2.39	> 400	0.72
		100	89.57	2.91		81.98	1.14		0.008
		200	50.5	8.42		70.99	3.32		0.03
		400	5.21	0.70		59.95	3.47		< 0.0001
	72 h	Control	100.16	0.61	192.5 ± 42.57	100.04	2.60	> 400	0.93
		100	77.25	12.73		80.72	6.00		0.74
		200	31.57	4.85		71.33	1.88		0.008
		400	2.33	0.57		55.84	0.08		< 0.0001
MDA-MB-468	24 h	Control	99.83	0.76	336.6 ± 20.84	100.47	1.75	> 400	0.57
		100	99.58	1.01		90.94	5.94		0.03
		200	83.32	2.55		86.50	5.73		0.40
		400	41.52	3.31		80.93	5.95		< 0.0001
	48 h	Control	100.06	0.40	334.1 ± 36.96	100.32	1.27	> 400	0.75
		100	95.61	5.86		85.32	5.84		0.02
		200	83.40	11.41		87.00	2.57		0.41
		400	41.48	11.72		73.54	6.87		< 0.0001
	72 h	Control	100.18	0.32	331.4 ± 7.24	100.53	0.92	> 400	0.56
		100	95.12	0.17		78.79	6.90		0.01
		200	83.83	1.65		76.2	7.92		0.23
		400	34.05	6.87		73.34	6.08		< 0.0001