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Table 2 Effect of l-Carnitine and Clomiphene citrate on serum metabolites of different groups in letrozole-induced PCOS rat model

From: Dysregulation of intraovarian redox status and steroidogenesis pathway in letrozole-induced PCOS rat model: a possible modulatory role of l-Carnitine

Parameters

C

PCOS

PCOS + LC

PCOS + CLO

Glucose (mg/dl)

92.20 ± 3.1a

190.38 ± 5.90b

128.25 ± 6.01c

136 ± 5.80c

TC (mg/dl)

92.23 ± 2.48a

181.92 ± 3.62b

128.17 ± 2.27c

152.50 ± 3.90d

TG (mg/dl)

59.97 ± 1.52a

92.12 ± 2.12b

74.20 ± 2.24c

74.67 ± 2.00c

HDL-C (mg/dl)

47.57 ± 2.34a

25.67 ± 1.66b

34.50 ± 1.36c

28.5 ± 1.60b

LDL-C (mg/dl)

32.67 ± 2.51a

137.83 ± 3.11b

78.83 ± 1.72c

109.1 ± 4.70d

VLDL-C (mg/dl)

11.99 ± 0.30a

18.42 ± 0.42b

14.84 ± 0.45c

14.93 ± 0.38c

CRI

TC/HDL-C

1.96 ± 0.10a

7.23 ± 0.45b

3.77 ± 0.10c

5.44 ± 0.36d

CRI

TG/HDL-C

1.28 ± 0.10a

3.67 ± 0.24b

2.17 ± 0.11c

2.64 ± 0.10d

TyG index

7.92 ± 0.05a

9.08 ± 0.04b

8.43 ± 0.07c

8.53 ± 0.06c

  1. TC Total Cholesterol, TG Triglycerides, HDL-C High Density Lipoprotein Cholesterol, LDL-C Low Density Lipoprotein Cholesterol, VLDL-C Very Low-Density Lipoprotein Cholesterol, TyG index Triglyceride Glucose Index, CRI Coronary risk index, C Control group, PCOS letrozole induced polycystic ovarian syndrome, PCOS + LC letrozole induced polycystic ovarian syndrome treated with l-Carnitine, PCOS + CLO letrozole induced polycystic ovarian syndrome treated with Clomiphene Citrate
  2. Values presented as mean ± SE (n = 6). Means denoted with different superscript letter in the same row are statistically significant at P < 0.05