Dysregulation of intraovarian redox status and steroidogenesis pathway in letrozole-induced PCOS rat model: a possible modulatory role of l-Carnitine

Beni-Suef University Journal of Basic and Applied Sciences

Table 3 Effect of l-Carnitine and Clomiphene citrate on hormonal assays of different groups in letrozole-induced PCOS rat model

Parameters	C	PCOS	PCOS + LC	PCOS + CLO
FSH (ng/dl)	11.92 ± 0.27^a	7.92 ± 0.58^b	12.33 ± 0.33^a	12.00 ± 0.29^a
LH (ng/dl)	5.65 ± 0.44^a	11.66 ± 0.38^b	8.40 ± 0.35^c	9.76 ± 0.28^c
LH/FSH	0.48 ± 0.04^a	1.52. ± 0.13^b	0.68 ± 0.04^a,c	0.82 ± 0.04^c
Testosterone (ng/ml)	0.32 ± 0.05^a	2.10 ± 0.10^b	1.23 ± 0.11^c	1.28 ± 0.03^c
17 β estradiol (pg/ml)	26.17 ± 1.14^a	12.08 ± 0.74^b	22.83 ± 1.45^c,a	19.92 ± 1.00^c

LH Luteinizing hormone, FSH Follicle stimulating hormone, C Control group, PCOS letrozole induced polycystic ovarian syndrome, PCOS + LC letrozole induced polycystic ovarian syndrome treated with l-Carnitine, PCOS + CLO letrozole induced polycystic ovarian syndrome treated with Clomiphene Citrate
Values presented as mean ± SE (n = 6). Means denoted with different superscript letters are statistically significant at P < 0.05