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Table 2 The target prediction and accessibility of C. longa miRNAs using the psRNATarget in silico tool

From: Employing in silico investigations to determine the cross-kingdom approach for Curcuma longa miRNAs and their human targets

miRNAs

Sequence

Targets

Inhibition

Probable Function

miRNAsstart

miRNAs end

Targets start

Targets end

Target aligned fragment

miRNA167

TGAAGCTGCCAGCATGATCTC

CUCUAGUACGACCGUCGAAGU

PPP3R2

Cleavage

Inhibit MAPK and GPCR pathway

1

21

1205

1225

UAUGUCAUGUUGGUAGCUUUA

miRNA1525

TGAGTTAATTAAGTTTTTATG

GUAUUUUUGAAUUAAUUGAGU

TNFSF15

Cleavage

Activate both the NF-κB and MAPK signalling pathways

Prevent apoptosis

Inhibits cell proliferation and angiogenesis

1

21

4011

4031

UAUAAAAGUUUAACUAACUCA

PCGF5

Cleavage

 

1

20

1953

1972

AUGGAAUUUUAAUUAACUCA

RHD

Cleavage

 

1

21

689

709

CAUAGAAACUUAAUUAGAUUA

YIPF6

Translation

Inhibits vesicle formation, trafficking, and budding

1

21

3017

3037

UAUAAAAACUCAAUUGAUUCC

SETD7

Cleavage

Inhibit expression of collagenase and insulin gene

Stabilizes p53/TP53 and increasing p53/TP53-mediated transcriptional activation

1

21

3614

3634

UAUAAAAAUUUAAAUCACUCA

DCC

Cleavage

Inhibits apoptosis

Reduces tumour suppressor activity

1

21

2914

2934

UAUAAAAAUUUAGAUAGUUCA

ATRN

Cleavage

Prevent obesity

Reduces inflammation

1

20

656

676

UAUAGUAACUUGAUUAAUUUA

SLC25A42

Cleavage

Alters mitochondrial transport of proteins

1

20

1992

2011

AUAAAAACUUAAAUGACUUC

CLEC2D

Cleavage

Prevent Osteoporosis type of condition

1

20

313

332

AAAGAGAUUUAAUUGACUCA

SRXN1

Translation

Reduces resistance to oxidative stress

Increases activity of anti-oxidative stress enzymes

1

20

2070

2089

AUAAAAGUUUAUUUAAUUUA

ALPK1

Cleavage

Influence neuronal coordination

1

20

769

788

AAAGAGGUUUAAUUAACUCA

ZFP36L1

Translation

Alters effect of growth factors and other cytokines

1

21

1151

1171

UAAAAAAGCUUAUUUAACUUA

HDX

Translation

Alter activity of several transcription factor

1

20

458

477

UUAAAAAAUUAUUUAACUCA

GAB1

Cleavage

Prevent tubulogenesis, cellular growth response, growth transformation and apoptosis

1

20

1945

1964

AUAAAUACAUGAUUAAUUCA

PNPO

Cleavage

Prevent epileptic changes

1

20

688

707

AUUACAACUUAACUAACUCA

miRNA1568

CGGCGTCGTCTTCGCTCCCGA

AGCCCUCGCUUCUGCUGCGGC

CD99L2

Cleavage

Prevent leucocyte infiltration and subsequent immune response

1

21

304

324

GCGGGGGCCAAGAUGAUGCUG

miRNA 129

TCCGGAGGGATCCCTTCCTTG

GUUCCUUCCCUAGGGAGGCCU

PGM3

Cleavage

Prevents glycogen storage and utilization

Prevent resistance to diabetic nephropathy and neuropathy

1

21

1901

1921

AAAGGAAGGGAUCCCUCAGGA

NAPB

Translation

Prevent amyotrophy and hereditary neuralgic

1

21

600

620

UGAGGAAGGGAGCUUUCUGGA

DLG2

Cleavage

Neurological role

1

21

483

503

AAAGAAAGGAAUCCCUUUGGA

miRNA 756

AGATCATCTGGCAGTTTCAAT

UAACUUUGACGGUCUACUAGA

CYB5B

Cleavage

Prevent accumulation of oxygenases

1

21

639

659

CUUAAAACUGCCAAAUGAUUU

ETV5

Cleavage

Prevent neurofibromatosis, type 2 and other neurological conditions

1

21

2206

2226

CUUGAACCUGCCAGCUGAUUU

GREM2

Cleavage

Prevent metastasis and cell migration differentiation

1

21

3138

3159

UUUGAAAUUGGCCAGAUGAUUU