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Table 2 Statistical summary of pharmacokinetic parameters for satranidazole drug and test formulation

From: Satranidazole-loaded chitosan/locust bean gum/xanthan gum polysaccharide composite multiunit pellets for colon targeting: in vitro–in vivo investigation

Pharmacokinetic parameters

Treatments

Result details

p-value

Cmax

Raw drug

Test formulation

Source

 

.00001(S)

N

X

Mean

X2

SD

N

X

Mean

X2

SD

Between treatments

Within treatments

SS

df

MS

SS

df

MS

F

 

6

306.4

51.06

15,654.2

1.21

6

210.1

35.01

7433.53

3.91

772.80

1

7772.80

83.90

10

8.39

92.10

 

tmax

6

15

2.5

39

0.54

6

15

2.5

39

0.54

0

1

0

3

10

0.3

0

1(NS)

AUC 0-t

6

2291.72

381.95

877,062.63

18.61

6

1872.02

312

589,088.95

31.66

14,679

1

14,679

6745.01

10

674.50

21.76

.00088(S)

AUC 0-α

6

2373.87

395.64

940,865.51

18.19

6

2000.77

333.46

673,059.51

34.29

11,600.300

1

11,600.300

7535.13

10

753.51

15.39

.00089(S)

kel

6

0.856

0.1427

0.1223

0.005

6

0.724

0.120

0.087

0.003

0.0015

1

0.0015

0.0002

10

0

63.49

.000012(S)

t1/2

6

29.18

4.8633

142.08

0.185

6

34.49

5.74

198.40

0.168

2.349

1

2.349

0.314

10

0.031

74.63

.00001(S)

  1. *Cmax Maximum plasma concentration, tmax Time to maximum plasma concentration, AUC0-t The area under plasma concentration time curve, AUC0-inf The area under plasma concentration time curve 0 to infinity, t1/2 Elimination half-life, Kel Elimination rate constant
  2. *N No of sample, ∑X Sum of sample, ∑X2 Sum of sample square, SD Standard deviation, SS Sum of square, df Degree of freedom, MS Mean square, F Test in one-way ANOVA
  3. *Significant and nonsignificant value indicates by S and NS