Pharmacokinetic parameters | Treatments | Result details | p-value | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cmax | Raw drug | Test formulation | Source | .00001(S) | ||||||||||||||
N | ∑X | Mean | ∑X2 | SD | N | ∑X | Mean | ∑X2 | SD | Between treatments | Within treatments | |||||||
SS | df | MS | SS | df | MS | F | ||||||||||||
6 | 306.4 | 51.06 | 15,654.2 | 1.21 | 6 | 210.1 | 35.01 | 7433.53 | 3.91 | 772.80 | 1 | 7772.80 | 83.90 | 10 | 8.39 | 92.10 | ||
tmax | 6 | 15 | 2.5 | 39 | 0.54 | 6 | 15 | 2.5 | 39 | 0.54 | 0 | 1 | 0 | 3 | 10 | 0.3 | 0 | 1(NS) |
AUC 0-t | 6 | 2291.72 | 381.95 | 877,062.63 | 18.61 | 6 | 1872.02 | 312 | 589,088.95 | 31.66 | 14,679 | 1 | 14,679 | 6745.01 | 10 | 674.50 | 21.76 | .00088(S) |
AUC 0-α | 6 | 2373.87 | 395.64 | 940,865.51 | 18.19 | 6 | 2000.77 | 333.46 | 673,059.51 | 34.29 | 11,600.300 | 1 | 11,600.300 | 7535.13 | 10 | 753.51 | 15.39 | .00089(S) |
kel | 6 | 0.856 | 0.1427 | 0.1223 | 0.005 | 6 | 0.724 | 0.120 | 0.087 | 0.003 | 0.0015 | 1 | 0.0015 | 0.0002 | 10 | 0 | 63.49 | .000012(S) |
t1/2 | 6 | 29.18 | 4.8633 | 142.08 | 0.185 | 6 | 34.49 | 5.74 | 198.40 | 0.168 | 2.349 | 1 | 2.349 | 0.314 | 10 | 0.031 | 74.63 | .00001(S) |