Pharmacokinetic parameters | Raw drug | Test formulation | p-value | ||
---|---|---|---|---|---|
Cmax (mcg. /ml.) | Mean | 51.07 | Mean | 35.02 | 0.00001(S) |
± S.D | 1.21 | ± S.D | 3.91 | ||
tmax (h) | Mean | 2.50 | Mean | 2.50 | 1(NS) |
± S.D | 0.55 | ± S.D | 0.55 | ||
AUC0-t (mcg. h/ml.) | Mean | 381.95 | Mean | 312.00 | 0.00088(S) |
± S.D | 18.61 | ± S.D | 31.66 | ||
AUC0-∞ (mcg. h/ml.) | Mean | 395.64 | Mean | 333.46 | 0.00089(S) |
± S.D | 18.20 | ± S.D | 34.29 | ||
kel (h−1) | Mean | 0.143 | Mean | 0.121 | 0.000012(S) |
± S.D | 0.006 | ± S.D | 0.004 | ||
t1/2 (h) | Mean | 4.86 | Mean | 5.75 | 0.00001(S) |
± S.D | 0.19 | ± S.D | 0.17 | ||
Relative bioavailability (%) | 100% | 81.69% | |||
Log-transformed (LN) relative bioavailability (%) | 100% | 96.60% |