Evaluation of CEP55, SERPINE1 and SMPD3 genes and proteins as diagnostic and prognostic biomarkers in gastric carcinoma in Egyptian patients

Abdel-Tawab, Marwa Sayed; Fouad, Hanan; Yehia Ismaeel, Ahmed; Tammam, Ahmed Abd-Eltawab; Fahmy, Alzhraa M.; Shaaban, Saeed; Abdel-Salam, Soha Mahmoud; Elazeem, Naglaa Adly Abd

doi:10.1186/s43088-022-00334-9

Beni-Suef University Journal of Basic and Applied Sciences

Table 2 Relations between the studied parameters, the demographic data and the tumor progression signs

From: Evaluation of CEP55, SERPINE1 and SMPD3 genes and proteins as diagnostic and prognostic biomarkers in gastric carcinoma in Egyptian patients

	N	CEP55 gene expression M ± SD	CEP55 protein (pg/ml) M ± SD	SERPINE1 gene expression M ± SD	SERPINE1 protein (ng/ml) M ± SD	SMPD3 gene expression M ± SD	SMPD3 protein (ng/ml) M ± SD
Studies samples
GC Tissues	30	0.046 ± .005	340.2 ± 95	4.4 ± 0.97	14.9 ± 2.6	0.35 ± 0.09	1.8 ± 0.66
Normal tissues	30	0.026 ± .007	148 ± 37	2.8 ± 0.33	7.2 ± 1.3	0.65 ± 0.07	3.5 ± 0.67
p value		p < 0.001	p < 0.001	p < 0.001	p < 0.001	p < 0.05	p < 0.001
Tumor size (cm)
Tumor size < 3	14	0.0453 ± .005	350.2 ± 108	3.7 ± 0.76	12.7 ± 1.6	0.39 ± 0.09	2.2 ± 0.48
Tumor size ≥ 3	16	0.0458 ± .006	332.5 ± 85	5 ± 0.67	16.8 ± 1.5	0.30 ± 0.07	1.38 ± 0.52
p value		p > 0.05	p > 0.05	p < 0.001	p < 0.001	p < 0.05	p < 0.001
Lymph nodes
Lymph nodes ≤ 3	12	0.046 ± .006	344 ± 100	3.8 ± 0.72	13.4 ± 1.6	0.39 ± 0.05	2.2 ± 0.48
Lymph nodes > 3	18	0.046 ± .005	338.8 ± 94.5	4.7 ± 0.95	15.9 ± 2.7	0.31 ± 0.09	1.48 ± 0.59
p value		p > 0.05	p > 0.05	p < 0.05	p < 0.05	p < 0.05	p < 0.05
Metastasis(organ)
Metastasis = 1	16	0.044 ± .005	342 ± 96	3.8 ± 0.88	13.6 ± 2.4	0.39 ± 0.08	2.2 ± 0.58
Metastasis > 1	14	0.047 ± .005	339 ± 97	5 ± 0.65	16.2 ± 2	0.29 ± 0.06	1.29 ± 0.34
p value		p > 0.05	p > 0.05	p < 0.001	p < 0.05	p < 0.05	p < 0.001
Tumor stages
Stage II	12	0.045 ± .005	343 ± 98	3.4 ± 0.52	12.6 ± 1.5	0.43 ± 0.05	2.5 ± 0.35
Stage III	8	0.047 ± .005	311 ± 87	4.8 ± 0.39	14.9 ± 1.8	0.33 ± 0.07	1.7 ± 0.20
Stage IV	10	0.046 ± .006	361 ± 99	5.1 ± 0.78	17.5 ± 1.3	0.26 ± 0.04	1 ± 0.18
p value		p > 0.05	p > 0.05	p< 0.001	p < 0.001	p < 0.001	p < 0.001
Tumor grades
G1	5	0.047 ± .007	323 ± 33	3.1 ± 0.51	12 ± 1.7	0.47 ± 0.06	2.6 ± 0.38
G2	9	0.047 ± .006	352 ± 107	3.8 ± 0.81	13.6 ± 2.3	0.39 ± 0.07	2.2 ± 0.60
G3	11	0.045 ± .003	306 ± 63	4.98 ± 0.51	15.8 ± 2	0.29 ± 0.06	1.45 ± 0.38
G4	5	0.044 ± .001	426 ± 134	4.92 ± 1.1	17 ± 1.7	0.28 ± 0.02	1.08 ± 0.27
p value		p > 0.05	p > 0.05	p < 0.001	p < 0.05	p < 0.001	p < 0.001
Age
< 60 years	22	0.046 ± .006	337 ± 99	4.4 ± 0.9	14.9 ± 2.8	0.35 ± 0.09	1.7 ± 0.68
≥ 60 years	8	0.044 ± .003	351 ± 87	4.3 ± 1.1	14.9 ± 2	0.34 ± 0.05	1.9 ± 0.62
p value		p > 0.05	p > 0.05	p > 0.05	p > 0.05	p > 0.05	p > 0.05
Gender
Male	17	0.044 ± .003	318 ± 79	4.3 ± 1	14.8 ± 2.8	0.35 ± 0.08	1.8 ± 0.75
Female	13	0.045 ± .005	370 ± 109	4.5 ± 0.9	14.9 ± 2.4	0.34 ± 0.09	1.7 ± 0.55
p value		p > 0.05	p > 0.05	p > 0.05	p > 0.05	p > 0.05	p > 0.05

CEP55; centrosomal protein-55, SERPINE1; serpin family E member 1, SMPD3; sphingomyelin phosphodiesterase 3, p < 0.001; Highly significant difference, p < 0.05; Significant difference, p > 0.05; Insignificant difference, M ± SD; mean ± standard deviation, N; number of cases

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