From: Vanillic acid attenuates testicular ischemia/reperfusion injury in rats
Sham control | T/D | T/D + VA (50 mg/kg) | T/D + VA (100 mg/kg) | |
---|---|---|---|---|
MDA (nmol/mg protein) | 9.65 (7.98–10.4) | 29.6 (23.4–31.2)a | 11.4 (9.18–20.1)b | 9.90 (7.30–12.8)b |
TOS (µmol H2O2 equivalent/L) | 18.9 (14.2–27.6) | 53.9 (50.7–57.9)a | 27.6 (17.2–40.1)b | 20.2 (15.6–26.7)b,c |
TAS (mmol trolox equivalent/L) | 1.24 (1.19–1.29) | 0.70 (0.67–0.75)a | 1.00 (0.89–1.10)a,b | 1.17 (1.07–1.19)b |
OSI (arbitrary unit) | 1.55 (1.11–2.22) | 7.52 (7.05–8.33)a | 2.62 (1.94–3.78)a,b | 1.73 (1.42–2.31)b |
8-OHdG (ng/mg protein) | 4.87 (3.88–5.64) | 14.1 (11.7–15.1)a | 8.36 (6.79–11.2)a,b | 4.79 (4.23–5.62)b,c |
SOD (ng/mg protein) | 1.49 (1.40–1.76) | 0.54 (0.44–0.62)a | 0.83 (0.64–1.12)a,b | 1.00 (0.89–1.52)b |
CAT (mIU/mg protein) | 7.20 (6.25–8.48) | 3.10 (2.63–3.30)a | 3.75 (2.78–5.20)a | 7.15 (5.85–8.53)b,c |
HMGB1 (pg/mg protein) | 46.0 (39.8–49.3) | 207.1 (175.0–226.6)a | 82.5 (47.1–129.9)a,b | 56.1 (50.6–58.5)b |
NF-κB p65 (pg/mg protein) | 105.5 (96.5–114.8) | 307.9 (285.1–323.9)a | 194.7 (145.4–314.3)a | 118.8 (106.9–139.9)b,c |
TNF-α (pg/mg protein) | 0.14 (0.12–0.15) | 0.74 (0.66–0.98)a | 0.38 (0.21–0.91)a | 0.10 (0.04–0.26)b,c |
IL-6 (pg/mg protein) | 30.6 (26.2–35.9) | 165.3 (156.0–189.6)a | 91.1 (80.1–109.2)a,b | 31.9 (28.5–38.3)b,c |
MPO (ng/mg protein) | 0.74 (0.65–0.80) | 1.76 (1.58–1.93)a | 1.03 (0.60–1.54)b | 0.73 (0.54–0.80)b |
GRP78 (pg/mg protein) | 34.5 (27.6–37.9) | 197.6 (163.5–223.4)a | 120.2 (85.2–159.0)a,b | 24.1 (21.0–36.5)b,c |
ATF6 (pg/mg protein) | 47.6 (33.4–58.7) | 174.1 (162.8–181.7)a | 81.7 (60.1–120.6)a,b | 45.6 (38.5–51.8)b,c |
CHOP (pg/mg protein) | 123.4 (106.4–146.1) | 323.2 (257.2–343.8)a | 187.4 (136.1–281.0)a,b | 145.5 (119.7–157.8)b |
Caspase-3 (ng/mg protein) | 0.16 (0.09–0.26) | 0.99 (0.74–1.08)a | 0.67 (0.47–0.86)a | 0.26 (0.18–0.28)b,c |
Johnsen scores | 9.5 (8–10) | 7 (6–8)a | 7.5 (7–8)a | 8 (8–9)b,c |