Beni-Suef University Journal of Basic and Applied Sciences

Table 1 The relation between clinical characteristics and treatment outcome in hepatitis C patients treated with SOF + DCV and healthy control

From: The relation between SNPs in the NME1 gene and response to sofosbuvir in Egyptian patients with chronic HCV

	Healthy control	HCV patients
	Healthy control	Responder N = 71	Non-responder N = 65	P value
Age (year)	35.8 ± 8.3	50.62 ± 8.47	59.73 ± 5.70	< 0.001
Fasting blood glucose (mg/dL)	87.8 ± 6.6	99.97 ± 25.06	93.00 ± 10.44	0.034
Serum Creatinine (mg/dL)	0.74 ± 0.11	0.85 ± 0.20	0.94 ± 0.18	0.009
White blood cell (χ10³/µl)	5.36 ± 0.79	5.48 ± 1.73	4.57 ± 1.22	0.001
Hemoglobin (g/L)	14.36 ± 1.05	13.50 ± 1.59	11.75 ± 1.88	< 0.001
Platelets (χ10³/µl)	308.04 ± 62.6	158.82 ± 57.64	177.86 ± 32.17	0.018
AST (IU/L)	26.92 ± 5.2	66.74 ± 39.12	69.42 ± 32.45	0.662
ALT (IU/L)	37.16 ± 13.25	65.32 ± 40.38	69.12 ± 30.90	0.536
Prothrombin concentration%	90.04 ± 3.5	88.89 ± 8.85	83.44 ± 22.11	0.219
Bilirubin (umol/L)	0.27 ± 0.08	0.91 ± 0.37	1.12 ± 0.29	< 0.001
Albumin (g/L)	4.09 ± 0.5	3.93 ± 0.42	4.17 ± 0.29	< 0.001
Alpha-fetoprotein (Log)	–	0.82 ± 0.49	0.54 ± 0.20	< 0.001
Baseline HCV RNA (log IU/mL)	–	5.00 ± 0.99	5.23 ± 0.88	0.161
Fibrosis-n (%)	–
FIB-4 < 1.45		41 (57.7%)	25 (37.9%)
FIB-4 = 1.45–3.25		10 (14.1%)	22 (33.3%)	0.016
FIB-4 > 3.25		20 (28.2%)	19 (28.8%)

ALT alanine aminotransferase, HCV hepatitis C virus, AST aspartate aminotransferase, N denotes to the number of patients or healthy controls. P values were calculated by Student’s t test (data are expressed as the mean and SD) and the chi-square test (The data are presented in the form of frequencies and percentages). Significant p values are highlighted in bold, and p ≤ 0.05 was considered significant

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