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Table 3 Association of rs1800460 and rs1127354 genotypes with adverse effects

From: Association of genetic polymorphism of NUDT15, TPMT and ITPA gene in the toxicity and efficacy of azathioprine-based regimen in Egyptian inflammatory bowel disease patients

Parameter

ITPA (rs1127354)

TPMT (rs1800460)

CC N = 141

CA N = 8

AA N = 1

p

CC N = 147

CT N = 3

p

Toxicity

N, %

106

75.2%

7

87.5%

0

0%

0.247

110

74.8%

3

100.0%

1

Fever

N, %

20

14.2%

1

12.5%

0

0%

0.913

21

14.3%

0

0.0%

0.480

Hypersensitivity and Rash

N, %

15

10.6%

1

12.5%

0

0%

0.929

15

10.2%

1

33.3%

0.289

Hemolysis

N, %

9

6.4%

0

0%

0

0%

0.737

8

5.4%

1

33.3%

0.170

Febrile neutropenia

N, %

9

6.4%

0

0%

0

0%

1

9

6.1%

0

0.0%

0.658

Myelosuppression

N, %

31

22.0%

7

87.5%

0

0%

 < 0.001

35

23.8%

3

100.0%

0.015

GIT intolerance

N, %

13

9.2%

0

0.0%

0

0%

1

11

7.5%

2

66.7%

0.020

Flu-like symptoms

N, %

26

18.4%

1

12.5%

0

0%

1

26

17.7%

1

33.3%

0.451

skin disorders

N, %

21

14.9%

1

12.5%

0

0%

1

21

14.3%

1

33.3%

0.381

Anemia

N, %

88

62.4%

2

25.0%

0

0%

0.036

87

59.2%

3

100.0%

0.275

leucopenia

N, %

22

15.6%

7

87.5%

0

0%

 < 0.001

26

17.7%

3

100.0%

0.007

Neutropenia

N, %

20

14.2%

1

12.5%

0

0%

1

21

14.3%

0

0.0%

1

Lymphopenia

N, %

39

27.7%

5

62.5%

0

0%

0.066

42

28.6%

2

66.7%

0.206

  1. OR odds ratio; CI confidence interval; GIT Gastrointestinal tract
  2. Bold values indicate significant results < 0.05