Parameter | ITPA (rs1127354) | TPMT (rs1800460) | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CC N = 141 | CA N = 8 | AA N = 1 | p | CC N = 147 | CT N = 3 | p | |||||||
Toxicity | N, % | 106 | 75.2% | 7 | 87.5% | 0 | 0% | 0.247 | 110 | 74.8% | 3 | 100.0% | 1 |
Fever | N, % | 20 | 14.2% | 1 | 12.5% | 0 | 0% | 0.913 | 21 | 14.3% | 0 | 0.0% | 0.480 |
Hypersensitivity and Rash | N, % | 15 | 10.6% | 1 | 12.5% | 0 | 0% | 0.929 | 15 | 10.2% | 1 | 33.3% | 0.289 |
Hemolysis | N, % | 9 | 6.4% | 0 | 0% | 0 | 0% | 0.737 | 8 | 5.4% | 1 | 33.3% | 0.170 |
Febrile neutropenia | N, % | 9 | 6.4% | 0 | 0% | 0 | 0% | 1 | 9 | 6.1% | 0 | 0.0% | 0.658 |
Myelosuppression | N, % | 31 | 22.0% | 7 | 87.5% | 0 | 0% |  < 0.001 | 35 | 23.8% | 3 | 100.0% | 0.015 |
GIT intolerance | N, % | 13 | 9.2% | 0 | 0.0% | 0 | 0% | 1 | 11 | 7.5% | 2 | 66.7% | 0.020 |
Flu-like symptoms | N, % | 26 | 18.4% | 1 | 12.5% | 0 | 0% | 1 | 26 | 17.7% | 1 | 33.3% | 0.451 |
skin disorders | N, % | 21 | 14.9% | 1 | 12.5% | 0 | 0% | 1 | 21 | 14.3% | 1 | 33.3% | 0.381 |
Anemia | N, % | 88 | 62.4% | 2 | 25.0% | 0 | 0% | 0.036 | 87 | 59.2% | 3 | 100.0% | 0.275 |
leucopenia | N, % | 22 | 15.6% | 7 | 87.5% | 0 | 0% |  < 0.001 | 26 | 17.7% | 3 | 100.0% | 0.007 |
Neutropenia | N, % | 20 | 14.2% | 1 | 12.5% | 0 | 0% | 1 | 21 | 14.3% | 0 | 0.0% | 1 |
Lymphopenia | N, % | 39 | 27.7% | 5 | 62.5% | 0 | 0% | 0.066 | 42 | 28.6% | 2 | 66.7% | 0.206 |