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Beni-Suef University Journal of Basic and Applied Sciences
Fig. 3 | Beni-Suef University Journal of Basic and Applied Sciences

Fig. 3

From: Modulatory effect of ginger on skeletal malformations, cell cycle, apoptosis and structural changes in the liver of rat fetuses prenatally exposed to labetalol

Fig. 3

Transmission electron micrographs of the fetal hepatocytes. a Control, b Ginger groups; euchromatic nucleus (N), regular well-identified nuclear envelope (Ne), prominent nucleolus (Nu), granular cytoplasm, glycogen granules (Gly), rough endoplasmic reticulum (rER) and numerous mitochondria (M). c–g Labetalol group; shrunken electron-dense nuclei (N), fragmented and swollen rough endoplasmic reticulum (red arrow), ruptured cell membrane and degenerated mitochondria (arrowhead). Destructed hepatocytes contain shrunken electron-dense nuclei (N), abnormal nuclear heterochromatin condensation, lysosomes (L), rarified cytoplasm (star), different inflammatory cells (black arrow) and red blood cells (RBC) among hepatocytes. h Labetalol + ginger group showing a hepatocyte with euchromatic nucleus (N), regular nuclear envelope (Ne), nucleolus (Nu), rough endoplasmic reticulum (rER), mitochondria (M) and some areas of an electron-lucent cytoplasm. Scale bar = 2 µm for all except (g) = 5 µm

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